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Gene Information
Gene Name
F2
Organism
Homo sapiens (Human)
Gene Length
622
Protein Names
Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
Target Name
coagulation factor iia
Target Type
Successful target
Gene Age
132 ( ENSG00000180210 )
Evolutionary Stage
Eumetazoa
AlphaFoldDB
P00734
Gene Card
F2
Uniprot ID
P00734
Pfam
PF00594; PF00051; PF09396; PF00089
In ASD
yes
Allosteric Prediction
yes (2.137585247)
Ortholog in Animals
Alpaca_ F2 ( ortholog_one2one )
Dog_ F2 ( ortholog_one2one )
GuineaPig_ F2 ( ortholog_one2one )
Macaque_ F2 ( ortholog_one2one )
Mouse_ F2 ( ortholog_one2one )
Pig_ F2 ( ortholog_one2one )
Rat_ F2 ( ortholog_one2one )
Ohnologs
NA
Paralogs
PAMR1
Tissue
liver, brain
Tissue Specificity
Expressed by the liver and secreted in plasma.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1A2C
(X-ray
2.10A
)
1A3B
(X-ray
1.80A
)
1A3E
(X-ray
1.85A
)
1A46
(X-ray
2.12A
)
1A4W
(X-ray
1.80A
)
1A5G
(X-ray
2.06A
)
1A61
(X-ray
2.20A
)
1ABI
(X-ray
2.30A
)
1ABJ
(X-ray
2.40A
)
1AD8
(X-ray
2.00A
)
1AE8
(X-ray
2.00A
)
1AFE
(X-ray
2.00A
)
1AHT
(X-ray
1.60A
)
1AI8
(X-ray
1.85A
)
1AIX
(X-ray
2.10A
)
1AWF
(X-ray
2.20A
)
1AWH
(X-ray
3.00A
)
1AY6
(X-ray
1.80A
)
1B5G
(X-ray
2.07A
)
1B7X
(X-ray
2.10A
)
1BA8
(X-ray
1.80A
)
1BB0
(X-ray
2.10A
)
1BCU
(X-ray
2.00A
)
1BHX
(X-ray
2.30A
)
1BMM
(X-ray
2.60A
)
1BMN
(X-ray
2.80A
)
1BTH
(X-ray
2.30A
)
1C1U
(X-ray
1.75A
)
1C1V
(X-ray
1.98A
)
1C1W
(X-ray
1.90A
)
1C4U
(X-ray
2.10A
)
1C4V
(X-ray
2.10A
)
1C4Y
(X-ray
2.70A
)
1C5L
(X-ray
1.47A
)
1C5N
(X-ray
1.50A
)
1C5O
(X-ray
1.90A
)
1CA8
(X-ray
2.10A
)
1D3D
(X-ray
2.04A
)
1D3P
(X-ray
2.10A
)
1D3Q
(X-ray
2.90A
)
1D3T
(X-ray
3.00A
)
1D4P
(X-ray
2.07A
)
1D6W
(X-ray
2.00A
)
1D9I
(X-ray
2.30A
)
1DE7
(X-ray
2.00A
)
1DIT
(X-ray
2.30A
)
1DM4
(X-ray
2.50A
)
1DOJ
(X-ray
1.70A
)
1DWB
(X-ray
3.16A
)
1DWC
(X-ray
3.00A
)
1DWD
(X-ray
3.00A
)
1DWE
(X-ray
3.00A
)
1DX5
(X-ray
2.30A
)
1E0F
(X-ray
3.10A
)
1EB1
(X-ray
1.80A
)
1EOJ
(X-ray
2.10A
)
1EOL
(X-ray
2.10A
)
1FPC
(X-ray
2.30A
)
1FPH
(X-ray
2.50A
)
1G30
(X-ray
2.00A
)
1G32
(X-ray
1.90A
)
1G37
(X-ray
2.00A
)
1GHV
(X-ray
1.85A
)
1GHW
(X-ray
1.75A
)
1GHX
(X-ray
1.65A
)
1GHY
(X-ray
1.85A
)
1GJ4
(X-ray
1.81A
)
1GJ5
(X-ray
1.73A
)
1H8D
(X-ray
1.40A
)
1H8I
(X-ray
1.75A
)
1HAG
(X-ray
2.00A
)
1HAH
(X-ray
2.30A
)
1HAI
(X-ray
2.40A
)
1HAO
(X-ray
2.80A
)
1HAP
(X-ray
2.80A
)
1HBT
(X-ray
2.00A
)
1HDT
(X-ray
2.60A
)
1HGT
(X-ray
2.20A
)
1HLT
(X-ray
3.00A
)
1HUT
(X-ray
2.90A
)
1HXE
(X-ray
2.10A
)
1HXF
(X-ray
2.10A
)
1IHS
(X-ray
2.00A
)
1IHT
(X-ray
2.10A
)
1JMO
(X-ray
2.20A
)
1JOU
(X-ray
1.80A
)
1JWT
(X-ray
2.50A
)
1K21
(X-ray
1.86A
)
1K22
(X-ray
1.93A
)
1KTS
(X-ray
2.40A
)
1KTT
(X-ray
2.10A
)
1LHC
(X-ray
1.95A
)
1LHD
(X-ray
2.35A
)
1LHE
(X-ray
2.25A
)
1LHF
(X-ray
2.40A
)
1LHG
(X-ray
2.25A
)
1MH0
(X-ray
2.80A
)
1MU6
(X-ray
1.99A
)
1MU8
(X-ray
2.00A
)
1MUE
(X-ray
2.00A
)
1NM6
(X-ray
1.80A
)
1NO9
(X-ray
1.90A
)
1NRN
(X-ray
3.10A
)
1NRO
(X-ray
3.10A
)
1NRP
(X-ray
3.00A
)
1NRQ
(X-ray
3.50A
)
1NRR
(X-ray
2.40A
)
1NRS
(X-ray
2.40A
)
1NT1
(X-ray
2.00A
)
1NU7
(X-ray
2.20A
)
1NU9
(X-ray
2.20A
)
1NY2
(X-ray
2.30A
)
1NZQ
(X-ray
2.18A
)
1O0D
(X-ray
2.44A
)
1O2G
(X-ray
1.58A
)
1O5G
(X-ray
1.75A
)
1OOK
(X-ray
2.30A
)
1OYT
(X-ray
1.67A
)
1P8V
(X-ray
2.60A
)
1PPB
(X-ray
1.92A
)
1QBV
(X-ray
1.80A
)
1QHR
(X-ray
2.20A
)
1QJ1
(X-ray
2.00A
)
1QJ6
(X-ray
2.20A
)
1QJ7
(X-ray
2.20A
)
1QUR
(X-ray
2.00A
)
1RD3
(X-ray
2.50A
)
1RIW
(X-ray
2.04A
)
1SB1
(X-ray
1.90A
)
1SFQ
(X-ray
1.91A
)
1SG8
(X-ray
2.30A
)
1SGI
(X-ray
2.30A
)
1SHH
(X-ray
1.55A
)
1SL3
(X-ray
1.81A
)
1SR5
(X-ray
3.10A
)
1T4U
(X-ray
2.00A
)
1T4V
(X-ray
2.00A
)
1TA2
(X-ray
2.30A
)
1TA6
(X-ray
1.90A
)
1TB6
(X-ray
2.50A
)
1TBZ
(X-ray
2.30A
)
1THP
(X-ray
2.10A
)
1THR
(X-ray
2.30A
)
1THS
(X-ray
2.20A
)
1TMB
(X-ray
2.30A
)
1TMT
(X-ray
2.20A
)
1TMU
(X-ray
2.50A
)
1TOM
(X-ray
1.80A
)
1TQ0
(X-ray
2.80A
)
1TQ7
(X-ray
2.40A
)
1TWX
(X-ray
2.40A
)
1UMA
(X-ray
2.00A
)
1UVS
(X-ray
2.80A
)
1VR1
(X-ray
1.90A
)
1VZQ
(X-ray
1.54A
)
1W7G
(X-ray
1.65A
)
1WAY
(X-ray
2.02A
)
1WBG
(X-ray
2.20A
)
1XM1
(X-ray
2.30A
)
1XMN
(X-ray
1.85A
)
1YPE
(X-ray
1.81A
)
1YPG
(X-ray
1.80A
)
1YPJ
(X-ray
1.78A
)
1YPK
(X-ray
1.78A
)
1YPL
(X-ray
1.85A
)
1YPM
(X-ray
1.85A
)
1Z71
(X-ray
1.80A
)
1Z8I
(X-ray
2.00A
)
1Z8J
(X-ray
2.00A
)
1ZGI
(X-ray
2.20A
)
1ZGV
(X-ray
2.20A
)
1ZRB
(X-ray
1.90A
)
2A0Q
(X-ray
1.90A
)
2A2X
(X-ray
2.44A
)
2A45
(X-ray
3.65A
)
2AFQ
(X-ray
1.93A
)
2ANK
(X-ray
2.46A
)
2ANM
(X-ray
2.40A
)
2B5T
(X-ray
2.10A
)
2BDY
(X-ray
1.61A
)
2BVR
(X-ray
1.25A
)
2BVS
(X-ray
1.40A
)
2BVX
(X-ray
3.20A
)
2BXT
(X-ray
1.83A
)
2BXU
(X-ray
2.80A
)
2C8W
(X-ray
1.96A
)
2C8X
(X-ray
2.17A
)
2C8Y
(X-ray
2.20A
)
2C8Z
(X-ray
2.14A
)
2C90
(X-ray
2.25A
)
2C93
(X-ray
2.20A
)
2CF8
(X-ray
1.30A
)
2CF9
(X-ray
1.79A
)
2CN0
(X-ray
1.30A
)
2FEQ
(X-ray
2.44A
)
2FES
(X-ray
2.42A
)
2GDE
(X-ray
2.00A
)
2GP9
(X-ray
1.87A
)
2H9T
(X-ray
2.40A
)
2HGT
(X-ray
2.20A
)
2HNT
(X-ray
2.50A
)
2HPP
(X-ray
3.30A
)
2HPQ
(X-ray
3.30A
)
2HWL
(X-ray
2.40A
)
2JH0
(X-ray
1.70A
)
2JH5
(X-ray
2.50A
)
2JH6
(X-ray
2.21A
)
2OD3
(X-ray
1.75A
)
2PGB
(X-ray
1.54A
)
2PGQ
(X-ray
1.80A
)
2PKS
(X-ray
2.50A
)
2PW8
(X-ray
1.84A
)
2R2M
(X-ray
2.10A
)
2THF
(X-ray
2.10A
)
2UUF
(X-ray
1.26A
)
2UUJ
(X-ray
1.32A
)
2UUK
(X-ray
1.39A
)
2V3H
(X-ray
1.79A
)
2V3O
(X-ray
1.79A
)
2ZC9
(X-ray
1.58A
)
2ZDA
(X-ray
1.73A
)
2ZDV
(X-ray
1.72A
)
2ZF0
(X-ray
2.20A
)
2ZFF
(X-ray
1.47A
)
2ZFP
(X-ray
2.25A
)
2ZFQ
(X-ray
1.80A
)
2ZFR
(X-ray
1.85A
)
2ZG0
(X-ray
1.75A
)
2ZGB
(X-ray
1.60A
)
2ZGX
(X-ray
1.80A
)
2ZHE
(X-ray
2.10A
)
2ZHF
(X-ray
1.98A
)
2ZHQ
(X-ray
1.96A
)
2ZHW
(X-ray
2.02A
)
2ZI2
(X-ray
1.65A
)
2ZIQ
(X-ray
1.65A
)
2ZNK
(X-ray
1.80A
)
2ZO3
(X-ray
1.70A
)
3B23
(X-ray
2.40A
)
3B9F
(X-ray
1.60A
)
3BEF
(X-ray
2.20A
)
3BEI
(X-ray
1.55A
)
3BF6
(X-ray
2.50A
)
3BIU
(X-ray
2.30A
)
3BIV
(X-ray
1.80A
)
3BV9
(X-ray
1.80A
)
3C1K
(X-ray
1.84A
)
3C27
(X-ray
2.18A
)
3D49
(X-ray
1.50A
)
3DA9
(X-ray
1.80A
)
3DD2
(X-ray
1.90A
)
3DHK
(X-ray
1.73A
)
3DT0
(X-ray
2.40A
)
3DUX
(X-ray
1.60A
)
3E6P
(X-ray
2.10A
)
3EE0
(X-ray
2.75A
)
3EGK
(X-ray
2.20A
)
3EQ0
(X-ray
1.53A
)
3F68
(X-ray
1.75A
)
3GIC
(X-ray
1.55A
)
3GIS
(X-ray
2.40A
)
3HAT
(X-ray
2.50A
)
3HKJ
(X-ray
2.60A
)
3HTC
(X-ray
2.30A
)
3JZ1
(X-ray
1.60A
)
3JZ2
(X-ray
2.40A
)
3K65
(X-ray
1.85A
)
3LDX
(X-ray
2.25A
)
3LU9
(X-ray
1.80A
)
3NXP
(X-ray
2.20A
)
3P17
(X-ray
1.43A
)
3P6Z
(X-ray
1.70A
)
3P70
(X-ray
2.55A
)
3PMH
(X-ray
3.20A
)
3PO1
(X-ray
1.65A
)
3QDZ
(X-ray
2.80A
)
3QGN
(X-ray
2.10A
)
3QLP
(X-ray
2.14A
)
3QTO
(X-ray
1.52A
)
3QTV
(X-ray
1.63A
)
3QWC
(X-ray
1.75A
)
3QX5
(X-ray
1.35A
)
3R3G
(X-ray
1.75A
)
3RLW
(X-ray
1.69A
)
3RLY
(X-ray
1.51A
)
3RM0
(X-ray
1.34A
)
3RM2
(X-ray
1.23A
)
3RML
(X-ray
1.53A
)
3RMM
(X-ray
1.58A
)
3RMN
(X-ray
1.78A
)
3RMO
(X-ray
1.40A
)
3S7H
(X-ray
1.90A
)
3S7K
(X-ray
1.90A
)
3SHA
(X-ray
1.52A
)
3SHC
(X-ray
1.90A
)
3SI3
(X-ray
1.55A
)
3SI4
(X-ray
1.27A
)
3SQE
(X-ray
1.90A
)
3SQH
(X-ray
2.20A
)
3SV2
(X-ray
1.30A
)
3T5F
(X-ray
1.45A
)
3TU7
(X-ray
2.49A
)
3U69
(X-ray
1.55A
)
3U8O
(X-ray
1.28A
)
3U8R
(X-ray
1.47A
)
3U8T
(X-ray
1.86A
)
3U98
(X-ray
1.45A
)
3U9A
(X-ray
1.58A
)
3UTU
(X-ray
1.55A
)
3UWJ
(X-ray
1.50A
)
3VXE
(X-ray
1.25A
)
3VXF
(Other
1.60A
)
4AX9
(X-ray
1.90A
)
4AYV
(X-ray
2.80A
)
4AYY
(X-ray
2.60A
)
4AZ2
(X-ray
2.60A
)
4BAH
(X-ray
1.94A
)
4BAK
(X-ray
1.94A
)
4BAM
(X-ray
1.88A
)
4BAN
(X-ray
1.87A
)
4BAO
(X-ray
1.87A
)
4BAQ
(X-ray
1.89A
)
4BOH
(X-ray
2.60A
)
4CH2
(X-ray
1.60A
)
4CH8
(X-ray
1.75A
)
4DIH
(X-ray
1.80A
)
4DII
(X-ray
2.05A
)
4DT7
(X-ray
1.90A
)
4DY7
(X-ray
2.80A
)
4E05
(X-ray
2.30A
)
4E06
(X-ray
3.20A
)
4E7R
(X-ray
2.25A
)
4H6S
(X-ray
2.19A
)
4H6T
(X-ray
2.40A
)
4HFP
(X-ray
2.40A
)
4HTC
(X-ray
2.30A
)
4HZH
(X-ray
3.30A
)
4I7Y
(X-ray
2.40A
)
4LOY
(X-ray
1.77A
)
4LXB
(X-ray
1.61A
)
4LZ1
(X-ray
1.65A
)
4LZ4
(X-ray
2.56A
)
4MLF
(X-ray
2.20A
)
4NZQ
(X-ray
2.81A
)
4O03
(X-ray
3.38A
)
4RKJ
(X-ray
1.70A
)
4RKO
(X-ray
1.84A
)
4RN6
(X-ray
3.00A
)
4THN
(X-ray
2.50A
)
4UD9
(X-ray
1.12A
)
4UDW
(X-ray
1.16A
)
4UE7
(X-ray
1.13A
)
4UEH
(X-ray
1.16A
)
4UFD
(X-ray
1.43A
)
4UFE
(X-ray
1.59A
)
4UFF
(X-ray
1.55A
)
4UFG
(X-ray
1.65A
)
4YES
(X-ray
1.50A
)
5A2M
(X-ray
1.40A
)
5AF9
(X-ray
1.18A
)
5AFY
(X-ray
1.12A
)
5AFZ
(X-ray
1.53A
)
5AHG
(X-ray
1.24A
)
5CMX
(X-ray
2.98A
)
5DO4
(X-ray
1.86A
)
5E8E
(X-ray
1.90A
)
5EDK
(X-ray
3.21A
)
5EDM
(X-ray
2.20A
)
5EW1
(X-ray
2.95A
)
5EW2
(X-ray
3.59A
)
5GDS
(X-ray
2.10A
)
5GIM
(X-ray
2.09A
)
5JDU
(X-ray
1.70A
)
5JFD
(X-ray
1.46A
)
5JZY
(X-ray
1.27A
)
5L6N
(X-ray
1.63A
)
5MJT
(X-ray
1.40A
)
5MLS
(X-ray
1.62A
)
5MM6
(X-ray
1.29A
)
5NHU
(X-ray
1.45A
)
5TO3
(X-ray
2.34A
)
5Z5W
(NMR
-
)
5Z5X
(NMR
-
)
6BJR
(X-ray
6.00A
)
6C2W
(X-ray
4.12A
)
6EO6
(X-ray
1.69A
)
6EO7
(X-ray
2.24A
)
6EO8
(X-ray
1.94A
)
6EO9
(X-ray
1.84A
)
6V5T
(X-ray
2.10A
)
7KME
(X-ray
2.10A
)
7TPP
(EM
4.10A
)
8KME
(X-ray
2.10A
)
DBSNP
rs5896
rs62623459
rs121918477
rs754231232
rs121918481
rs5897
rs121918479
rs121918482
rs121918478
rs121918480
Subcellular location [CC]
Secreted, extracellular space.
Mouse PG classification
HPG
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