Gene Information
Gene NameF12
OrganismHomo sapiens (Human)
Gene Length615
Protein NamesCoagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]
Target Namefactor xii messenger rna
Target TypeClinical trial target
Gene Age950 ( ENSG00000131187 )
Evolutionary StageVertebrata
AlphaFoldDBP00748
Gene CardF12
Uniprot IDP00748
PfamPF00008; PF00039; PF00040; PF00051; PF00089
In ASDno
Allosteric Predictionyes (0.626005832)
Ortholog in AnimalsAlpaca_ F12 ( ortholog_one2one )
Dog_ F12 ( ortholog_one2one )
GuineaPig_ F12 ( ortholog_one2one )
Macaque_ F12 ( ortholog_one2one )
Mouse_ F12 ( ortholog_one2one )
Pig_ F12 ( ortholog_one2one )
Rat_ F12 ( ortholog_one2one )
Rabbit_ F12 ( ortholog_one2one )
OhnologsPLAT, PLAU, HABP2
ParalogsHGFAC, F7, C1R, KLK10, F9, F10, CFI, CFD, PRSS55, PRSS51, C1S, C1RL, HP, HPR, KLKB1, F11
Tissueliver
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4BDW  (X-ray  2.50A  )  4BDX  (X-ray  1.62A  )  4XDE  (X-ray  2.14A  )  4XE4  (X-ray  2.40A  )  6B74  (X-ray  2.32A  )  6B77  (X-ray  2.37A  )  6GT6  (X-ray  2.54A  )  6L63  (X-ray  3.00A  )  6QF7  (X-ray  4.00A  )  6SZW  (X-ray  3.14A  )  6X0S  (X-ray  1.90A  )  6X0T  (X-ray  1.39A  )  7FBP  (X-ray  1.99A  ) 
DBSNP rs118204455  rs17876030  rs118204456  rs118204456  rs2230939  rs118204454  rs865853663  rs932430490  rs17876034  rs766505234  rs1157280571  rs17876035 
Subcellular location [CC]Secreted.
Mouse PG classificationLPG
click here to return to the previous page