| Gene Information | |
|---|---|
| Gene Name | ROCK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1388 |
| Protein Names | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) |
| Target Name | rho-associated protein kinase 2 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000134318 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O75116 |
| Gene Card | ROCK2 |
| Uniprot ID | O75116 |
| Pfam | PF00069; PF08912 |
| In ASD | no |
| Allosteric Prediction | yes (0.785027843) |
| Ortholog in Animals | Alpaca_ ROCK2 ( ortholog_one2one ) Dog_ ROCK2 ( ortholog_one2one ) GuineaPig_ ROCK2 ( ortholog_one2one ) Macaque_ ROCK2 ( ortholog_one2one ) Mouse_ Rock2 ( ortholog_one2one ) Pig_ ROCK2 ( ortholog_one2one ) Rat_ Rock2 ( ortholog_one2one ) Rabbit_ ROCK2 ( ortholog_one2one ) |
| Ohnologs | ROCK1 |
| Paralogs | ROCK1, CIT, CDC42BPA, CDC42BPG, CDC42BPB |
| Tissue | NA |
| Tissue Specificity | Expressed in the brain (at protein level). {ECO:0000269|PubMed:21147781}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4L6Q (X-ray 2.79A ) 4WOT (X-ray 2.93A ) 5U7Q (X-ray 3.15A ) 5U7R (X-ray 3.33A ) 6ED6 (X-ray 2.86A ) 6P5M (X-ray 2.65A ) 6P5P (X-ray 3.30A ) 7JNT (X-ray 2.21A ) 7JOV (X-ray 2.59A ) 7P6N (X-ray 3.00A ) |
| DBSNP | rs2230774 rs35768389 rs34945852 |
| Subcellular location [CC] | Cytoplasm. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane. {ECO:0000250}. |
| Mouse PG classification | NA |
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