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Gene Information
Gene Name
F11
Organism
Homo sapiens (Human)
Gene Length
625
Protein Names
Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
Target Name
coagulation factor xi
Target Type
Clinical trial target
Gene Age
454 ( ENSG00000088926 )
Evolutionary Stage
Eumetazoa
AlphaFoldDB
P03951
Gene Card
F11
Uniprot ID
P03951
Pfam
PF00024; PF00089
In ASD
yes
Allosteric Prediction
yes (0.999773207)
Ortholog in Animals
Alpaca_ F11 ( ortholog_one2one )
Dog_ F11 ( ortholog_one2one )
GuineaPig_ F11 ( ortholog_one2one )
Macaque_ F11 ( ortholog_one2one )
Mouse_ F11 ( ortholog_one2one )
Pig_ F11 ( ortholog_one2one )
Rat_ F11 ( ortholog_one2one )
Rabbit_ F11 ( ortholog_one2one )
Ohnologs
NA
Paralogs
HGFAC, F7, C1R, KLK10, F9, F12, F10, CFI, CFD, PRSS55, PRSS51, C1S, C1RL, HP, HPR, KLKB1
Tissue
liver
Tissue Specificity
Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1XX9
(X-ray
2.20A
)
1XXD
(X-ray
2.91A
)
1XXF
(X-ray
2.60A
)
1ZHM
(X-ray
1.96A
)
1ZHP
(X-ray
2.70A
)
1ZHR
(X-ray
1.73A
)
1ZJD
(X-ray
2.60A
)
1ZLR
(X-ray
2.50A
)
1ZMJ
(X-ray
2.00A
)
1ZML
(X-ray
2.25A
)
1ZMN
(X-ray
2.05A
)
1ZOM
(X-ray
2.25A
)
1ZPB
(X-ray
2.10A
)
1ZPC
(X-ray
2.60A
)
1ZPZ
(X-ray
2.50A
)
1ZRK
(X-ray
2.30A
)
1ZSJ
(X-ray
1.90A
)
1ZSK
(X-ray
1.90A
)
1ZSL
(X-ray
2.05A
)
1ZTJ
(X-ray
2.05A
)
1ZTK
(X-ray
2.50A
)
1ZTL
(X-ray
2.60A
)
2F83
2FDA
(X-ray
2.00A
)
2J8J
(NMR
-
)
2J8L
(NMR
-
)
3BG8
(X-ray
1.60A
)
3SOR
(X-ray
1.80A
)
3SOS
(X-ray
2.58A
)
4CR5
(X-ray
2.00A
)
4CR9
(X-ray
1.70A
)
4CRA
(X-ray
1.80A
)
4CRB
(X-ray
1.85A
)
4CRC
(X-ray
1.60A
)
4CRD
(X-ray
2.10A
)
4CRE
(X-ray
1.73A
)
4CRF
(X-ray
2.30A
)
4CRG
(X-ray
1.25A
)
4D76
(X-ray
1.77A
)
4D7F
(X-ray
1.62A
)
4D7G
(X-ray
2.33A
)
4NA7
(X-ray
2.80A
)
4NA8
(X-ray
2.30A
)
4TY6
(X-ray
1.85A
)
4TY7
(X-ray
2.09A
)
4WXI
(X-ray
2.60A
)
4X6M
(X-ray
2.40A
)
4X6N
(X-ray
2.10A
)
4X6O
(X-ray
2.10A
)
4X6P
(X-ray
1.93A
)
4Y8X
(X-ray
1.90A
)
4Y8Y
(X-ray
2.60A
)
4Y8Z
(X-ray
2.20A
)
5E2O
(X-ray
2.08A
)
5E2P
(X-ray
2.11A
)
5EOD
(X-ray
3.10A
)
5EOK
(X-ray
2.80A
)
5EXL
(X-ray
2.30A
)
5EXM
(X-ray
2.09A
)
5EXN
(X-ray
1.49A
)
5I25
(X-ray
2.85A
)
5Q0D
(X-ray
2.12A
)
5Q0E
(X-ray
2.12A
)
5Q0F
(X-ray
2.12A
)
5Q0G
(X-ray
2.60A
)
5Q0H
(X-ray
2.50A
)
5QCK
(X-ray
2.64A
)
5QCL
(X-ray
2.11A
)
5QCM
(X-ray
2.20A
)
5QCN
(X-ray
2.30A
)
5QQO
(X-ray
2.00A
)
5QQP
(X-ray
2.08A
)
5QTT
(X-ray
2.23A
)
5QTV
(X-ray
2.20A
)
5QTW
(X-ray
2.12A
)
5QTY
(X-ray
1.89A
)
5TKS
(X-ray
1.55A
)
5TKT
(X-ray
2.12A
)
5TKU
(X-ray
2.12A
)
5WB6
(X-ray
2.35A
)
6AOD
(X-ray
1.80A
)
6C0S
(X-ray
2.35A
)
6HHC
(X-ray
2.70A
)
6I58
(X-ray
2.60A
)
6R8X
(X-ray
2.04A
)
6TS4
(X-ray
1.17A
)
6TS5
(X-ray
1.29A
)
6TS6
(X-ray
1.33A
)
6TS7
(X-ray
2.63A
)
6TWB
(X-ray
2.91A
)
6USY
(X-ray
1.26A
)
6VLU
(X-ray
1.60A
)
6VLV
(X-ray
1.72A
)
6W50
(X-ray
1.95A
)
7CJ1
(X-ray
3.00A
)
7MBO
(X-ray
0.92A
)
7V0Z
(X-ray
1.80A
)
7V10
(X-ray
1.80A
)
7V11
(X-ray
1.47A
)
7V12
(X-ray
1.63A
)
7V13
(X-ray
1.59A
)
7V14
(X-ray
1.70A
)
7V15
(X-ray
1.68A
)
7V16
(X-ray
1.50A
)
7V17
(X-ray
1.52A
)
7V18
(X-ray
1.73A
)
DBSNP
rs281875259
rs281875267
rs281875264
rs281875271
rs281875252
rs281875243
rs281875261
rs121965069
rs281875244
rs5968
rs281875272
rs768474112
rs281875256
rs281875273
rs281875245
rs281875246
rs281875265
rs5969
rs281875279
rs281875260
rs281875277
rs281875274
rs145168351
rs121965070
rs281875247
rs281875248
rs121965064
rs5972
rs281875257
rs281875268
rs281875269
rs28934608
rs281875253
rs5967
rs281875270
rs281875254
rs1800439
rs281875262
rs281875266
rs121965067
rs121965071
rs121965068
rs281875241
rs121965065
rs281875242
rs1554083754
rs140068026
rs281875258
rs281875278
rs281875249
rs281875263
rs139695003
rs142952627
rs369935706
rs281875275
rs281875250
rs121965072
rs28934609
rs281875251
rs281875255
rs281875276
Subcellular location [CC]
Secreted.
Mouse PG classification
NA
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