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Gene Information
Gene Name
F10
Organism
Homo sapiens (Human)
Gene Length
488
Protein Names
Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
Target Name
coagulation factor x
Target Type
NA
Gene Age
950 ( ENSG00000126218 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
P00742
Gene Card
F10
Uniprot ID
P00742
Pfam
PF00008; PF00594; PF00089
In ASD
yes
Allosteric Prediction
yes (1.399927456)
Ortholog in Animals
Alpaca_ F10 ( ortholog_one2many )
Dog_ F10 ( ortholog_one2one )
GuineaPig_ F10 ( ortholog_one2one )
Macaque_ F10 ( ortholog_one2one )
Mouse_ F10 ( ortholog_one2one )
Pig_ F10 ( ortholog_one2one )
Rat_ F10 ( ortholog_one2one )
Rabbit_ F10 ( ortholog_one2one )
Ohnologs
F9, PRSS3, PROC
Paralogs
HGFAC, F7, C1R, KLK10, F9, F12, CFI, CFD, PRSS55, PRSS51, C1S, C1RL, HP, HPR, KLKB1, F11
Tissue
NA
Tissue Specificity
Plasma;
synthesized in the liver. {ECO:0000269|PubMed:6587384}.
Pharmacological Animal Models
0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.033333(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1C5M
(X-ray
1.95A
)
1EZQ
(X-ray
2.20A
)
1F0R
(X-ray
2.10A
)
1F0S
(X-ray
2.10A
)
1FAX
(X-ray
3.00A
)
1FJS
(X-ray
1.92A
)
1FXY
(X-ray
2.15A
)
1G2L
(X-ray
1.90A
)
1G2M
(X-ray
3.02A
)
1HCG
(X-ray
2.20A
)
1IOE
(X-ray
2.90A
)
1IQE
(X-ray
2.90A
)
1IQF
(X-ray
3.20A
)
1IQG
(X-ray
2.60A
)
1IQH
(X-ray
3.00A
)
1IQI
(X-ray
2.90A
)
1IQJ
(X-ray
3.00A
)
1IQK
(X-ray
3.20A
)
1IQL
(X-ray
2.70A
)
1IQM
(X-ray
2.60A
)
1IQN
(X-ray
2.60A
)
1KSN
(X-ray
2.10A
)
1LPG
(X-ray
2.00A
)
1LPK
(X-ray
2.20A
)
1LPZ
(X-ray
2.40A
)
1LQD
(X-ray
2.70A
)
1MQ5
(X-ray
2.10A
)
1MQ6
(X-ray
2.10A
)
1NFU
(X-ray
2.05A
)
1NFW
(X-ray
2.10A
)
1NFX
(X-ray
2.15A
)
1NFY
(X-ray
2.10A
)
1P0S
(X-ray
2.80A
)
1V3X
(X-ray
2.20A
)
1WU1
(X-ray
2.30A
)
1XKA
(X-ray
2.30A
)
1XKB
(X-ray
2.40A
)
1Z6E
(X-ray
1.80A
)
2BMG
(X-ray
2.70A
)
2BOH
(X-ray
2.20A
)
2BOK
(X-ray
1.64A
)
2BQ6
(X-ray
3.00A
)
2BQ7
(X-ray
2.20A
)
2BQW
(X-ray
2.95A
)
2CJI
(X-ray
2.10A
)
2D1J
(X-ray
2.20A
)
2EI6
(X-ray
2.30A
)
2EI7
(X-ray
2.30A
)
2EI8
(X-ray
2.10A
)
2FZZ
(X-ray
2.20A
)
2G00
(X-ray
2.10A
)
2GD4
(X-ray
3.30A
)
2H9E
(X-ray
2.20A
)
2J2U
(X-ray
1.90A
)
2J34
(X-ray
2.01A
)
2J38
(X-ray
2.10A
)
2J4I
(X-ray
1.80A
)
2J94
(X-ray
2.10A
)
2J95
(X-ray
2.01A
)
2JKH
(X-ray
1.25A
)
2P16
(X-ray
2.30A
)
2P3F
(X-ray
3.10A
)
2P3T
(X-ray
1.92A
)
2P3U
(X-ray
1.62A
)
2P93
(X-ray
1.90A
)
2P94
(X-ray
1.80A
)
2P95
(X-ray
2.20A
)
2PHB
(X-ray
2.30A
)
2PR3
(X-ray
1.50A
)
2Q1J
(X-ray
1.90A
)
2RA0
(X-ray
2.30A
)
2UWL
(X-ray
1.90A
)
2UWO
(X-ray
1.75A
)
2UWP
(X-ray
1.75A
)
2VH0
(X-ray
1.70A
)
2VH6
(X-ray
1.95A
)
2VVC
(X-ray
1.95A
)
2VVU
(X-ray
2.30A
)
2VVV
(X-ray
1.73A
)
2VWL
(X-ray
1.80A
)
2VWM
(X-ray
1.96A
)
2VWN
(X-ray
1.61A
)
2VWO
(X-ray
1.60A
)
2W26
(X-ray
2.08A
)
2W3I
(X-ray
1.90A
)
2W3K
(X-ray
2.05A
)
2WYG
(X-ray
1.88A
)
2WYJ
(X-ray
2.38A
)
2XBV
(X-ray
1.66A
)
2XBW
(X-ray
1.72A
)
2XBX
(X-ray
1.85A
)
2XBY
(X-ray
2.02A
)
2XC0
(X-ray
2.05A
)
2XC4
(X-ray
1.67A
)
2XC5
(X-ray
1.70A
)
2Y5F
(X-ray
1.29A
)
2Y5G
(X-ray
1.29A
)
2Y5H
(X-ray
1.33A
)
2Y7X
(X-ray
1.90A
)
2Y7Z
(X-ray
1.84A
)
2Y80
(X-ray
1.90A
)
2Y81
(X-ray
1.70A
)
2Y82
(X-ray
2.20A
)
3CEN
(X-ray
1.60A
)
3CS7
(X-ray
2.20A
)
3ENS
(X-ray
2.30A
)
3FFG
(X-ray
1.54A
)
3HPT
(X-ray
2.19A
)
3IIT
(X-ray
1.80A
)
3K9X
(X-ray
1.90A
)
3KL6
(X-ray
1.45A
)
3KQB
(X-ray
2.25A
)
3KQC
(X-ray
2.20A
)
3KQD
(X-ray
2.75A
)
3KQE
(X-ray
2.35A
)
3LIW
(X-ray
2.22A
)
3M36
(X-ray
2.15A
)
3M37
(X-ray
1.90A
)
3Q3K
(X-ray
2.00A
)
3SW2
(X-ray
2.42A
)
3TK5
(X-ray
2.20A
)
3TK6
(X-ray
1.80A
)
4A7I
(X-ray
2.40A
)
4BTI
(X-ray
2.30A
)
4BTT
(X-ray
2.59A
)
4BTU
(X-ray
2.37A
)
4Y6D
(X-ray
1.55A
)
4Y71
(X-ray
1.80A
)
4Y76
(X-ray
2.00A
)
4Y79
(X-ray
2.10A
)
4Y7A
(X-ray
1.99A
)
4Y7B
(X-ray
1.79A
)
4ZH8
(X-ray
1.80A
)
4ZHA
(X-ray
1.86A
)
5JQY
(X-ray
1.99A
)
5JTC
(X-ray
2.24A
)
5JZ8
(X-ray
2.10A
)
5JZU
(X-ray
2.50A
)
5K0H
(X-ray
2.20A
)
5VOE
(X-ray
2.00A
)
5VOF
(X-ray
2.25A
)
6Q9F
(X-ray
1.63A
)
6Q9I
(X-ray
1.85A
)
6RK9
(X-ray
2.29A
)
6YYW
(X-ray
2.27A
)
6YYX
(X-ray
1.53A
)
6YYY
(X-ray
2.29A
)
6Z6Q
(X-ray
1.81A
)
6Z6R
(X-ray
2.13A
)
7AHU
(X-ray
2.60A
)
7BMI
(X-ray
1.66A
)
7BMJ
(X-ray
1.75A
)
7E6J
(X-ray
1.90A
)
7TPP
(EM
4.10A
)
7TPQ
(EM
5.30A
)
DBSNP
rs5963
rs5961
rs121964943
rs751782758
rs121964944
rs121964939
rs121964945
rs1477329751
rs61753266
rs3211772
rs3211783
rs1393705267
rs121964946
rs747292771
rs121964942
rs770119164
rs121964947
rs372309538
rs768222784
rs1595099527
rs104894392
rs121964941
rs121964940
rs199778916
rs1595099645
rs376163818
rs750759634
rs758726161
Subcellular location [CC]
Secreted.
Mouse PG classification
NA
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