Gene Information
Gene NameEZR
OrganismHomo sapiens (Human)
Gene Length586
Protein NamesEzrin (Cytovillin) (Villin-2) (p81)
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000092820 )
Evolutionary StageVertebrata
AlphaFoldDBP15311
Gene CardEZR
Uniprot IDP15311
PfamPF00769; PF20492; PF09380; PF00373; PF09379
In ASDno
Allosteric Predictionyes (1.090337233)
Ortholog in AnimalsAlpaca_ EZR ( ortholog_one2one )
Dog_ EZR ( ortholog_one2one )
GuineaPig_ EZR ( ortholog_one2one )
Macaque_ EZR ( ortholog_one2one )
Mouse_ Ezr ( ortholog_one2one )
Pig_ EZR ( ortholog_one2one )
Rat_ Ezr ( ortholog_one2one )
Rabbit_ EZR ( ortholog_one2one )
OhnologsRDX, MSN
ParalogsMSN, RDX, FRMD4B, NF2, ERMN, FRMD4A
TissueNA
Tissue SpecificityExpressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. {ECO:0000269|PubMed:15797715}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1NI2  (X-ray  2.30A  4RM8  (X-ray  1.90A  4RM9  (X-ray  2.00A  4RMA  (X-ray  1.75A  7T1K  (X-ray  1.25A  7T1L  (X-ray  1.35A 
DBSNP rs3103004  rs2230143 
Subcellular location [CC]Apical cell membrane {ECO:0000269|PubMed:18046454};
Peripheral membrane protein {ECO:0000269|PubMed:18046454};
Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection {ECO:0000269|PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269|PubMed:18046454};
Peripheral membrane protein {ECO:0000269|PubMed:18046454};
Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18046454};
Peripheral membrane protein {ECO:0000269|PubMed:18046454};
Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18046454}. Cell projection, microvillus {ECO:0000250|UniProtKB:P26040}. Note=Localization to the apical membrane of parietal cells depends on the interaction with PALS1. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250|UniProtKB:P31977}.
Mouse PG classificationNA
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