| Gene Information | |
|---|---|
| Gene Name | RAD50 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1312 |
| Protein Names | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000113522 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q92878 |
| Gene Card | RAD50 |
| Uniprot ID | Q92878 |
| Pfam | PF13476; PF04423 |
| In ASD | no |
| Allosteric Prediction | yes (0.452051653) |
| Ortholog in Animals | Alpaca_ RAD50 ( ortholog_one2one ) Alpaca_ RAD50 ( ortholog_one2many ) Dog_ RAD50 ( ortholog_one2one ) GuineaPig_ RAD50 ( ortholog_one2one ) Macaque_ RAD50 ( ortholog_one2one ) Mouse_ Rad50 ( ortholog_one2one ) Pig_ RAD50 ( ortholog_one2one ) Rat_ Rad50 ( ortholog_one2one ) Rabbit_ RAD50 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at very low level in most tissues, except in testis where it is expressed at higher level. Expressed in fibroblasts. {ECO:0000269|PubMed:8756642}. |
| Pharmacological Animal Models | 0.022588(Chimpanzee);0.048970(Mouse);0.347930(Rat);0.092033(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5GOX (X-ray 2.40A ) |
| DBSNP | rs28903085 rs28903086 rs2230017 rs28903087 rs28903088 rs28903090 rs55653181 rs1047380 rs1047382 rs28903093 rs1047386 rs1129482 rs1047387 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:26215093}. Chromosome, telomere {ECO:0000269|PubMed:10888888}. Chromosome {ECO:0000269|PubMed:26215093}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:26215093}. |
| Mouse PG classification | LPG |
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