| Gene Information | |
|---|---|
| Gene Name | EZH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 746 |
| Protein Names | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) |
| Target Name | ezh2 y641n mutant |
| Target Type | Patented-recorded target |
| Gene Age | 987 ( ENSG00000106462 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15910 |
| Gene Card | EZH2 |
| Uniprot ID | Q15910 |
| Pfam | PF11616; PF18118; PF18264; PF00856 |
| In ASD | yes |
| Allosteric Prediction | yes (1.528133879) |
| Ortholog in Animals | Alpaca_ EZH2 ( ortholog_one2one ) Alpaca_ EZH2 ( ortholog_one2many ) Dog_ EZH2 ( ortholog_one2one ) GuineaPig_ EZH2 ( ortholog_one2one ) Macaque_ EZH2 ( ortholog_one2one ) Mouse_ Ezh2 ( ortholog_one2one ) Pig_ EZH2 ( ortholog_one2one ) Rat_ Ezh2 ( ortholog_one2one ) Rabbit_ EZH2 ( ortholog_one2one ) |
| Ohnologs | EZH1 |
| Paralogs | KMT2B, ASH1L, NSD3, EHMT2, SUV39H1, EZH1, KMT2A, SETBP1, SETD2, SETD1B, SETD1A, SUV39H2, EHMT1, KMT2D, NSD2, SETDB2, KMT2C, NSD1, SETDB1 |
| Tissue | testis |
| Tissue Specificity | In the ovary, expressed in primordial follicles and oocytes and also in external follicle cells (at protein level) (PubMed:31451685). Expressed in many tissues (PubMed:14532106). Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis (PubMed:14532106). {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:31451685}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.059753(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4MI0 (X-ray 2.00A ) 4MI5 (X-ray 2.00A ) 5GSA (X-ray 2.49A ) 5H14 (X-ray 1.90A ) 5H15 (X-ray 2.27A ) 5H17 (X-ray 2.30A ) 5H19 (X-ray 1.90A ) 5H24 (X-ray 2.50A ) 5H25 (X-ray 2.88A ) 5HYN (X-ray 2.95A ) 5IJ7 (X-ray 2.62A ) 5IJ8 (X-ray 2.99A ) 5LS6 (X-ray 3.47A ) 5U5T (X-ray 1.60A ) 5U62 (X-ray 1.90A ) 5WG6 (X-ray 3.90A ) 5WUK (X-ray 2.03A ) 6C23 (EM 3.90A ) 6C24 (EM 3.50A ) 6LO2 (X-ray 2.21A ) 6P5L (X-ray 3.30A ) 6U4Y (X-ray 2.91A ) 6WKR (EM 3.50A ) 7AT8 (EM 4.40A ) 7QJG (X-ray 1.80A ) 7QJU (X-ray 1.80A ) 7QK4 (X-ray 1.60A ) |
| DBSNP | rs193921148 rs193921146 rs2302427 rs587783625 rs267601394 rs267601395 rs267601395 rs267601394 rs1057519833 rs397515547 rs587783626 rs1554481435 rs193921147 rs397515548 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12101246, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:9584199}. Note=Localizes to the inactive X chromosome in trophoblast stem cells. {ECO:0000250|UniProtKB:Q61188}. |
| Mouse PG classification | LPG |
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