| Gene Information | |
|---|---|
| Gene Name | SORBS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1100 |
| Protein Names | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000154556 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O94875 |
| Gene Card | SORBS2 |
| Uniprot ID | O94875 |
| Pfam | PF00018; PF14604; PF02208 |
| In ASD | no |
| Allosteric Prediction | no (-0.272535057) |
| Ortholog in Animals | Alpaca_ SORBS2 ( ortholog_one2one ) Dog_ SORBS2 ( ortholog_one2one ) GuineaPig_ SORBS2 ( ortholog_one2one ) Macaque_ SORBS2 ( ortholog_one2one ) Mouse_ Sorbs2 ( ortholog_one2one ) Pig_ SORBS2 ( ortholog_one2one ) Rat_ Sorbs2 ( ortholog_one2one ) Rabbit_ SORBS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SH3GL3, SORBS1, SH3GLB1, SORBS3, SH3GLB2, NCF4, SH3RF3, SH3RF2, SH3GL1, SH3RF1, SH3D19, SH3GL2 |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. In the pancreas, mainly expressed in acinar cells, duct cells and all cell types in islets (at protein level). Tends to be down-regulated in pancreatic adenocarcinomas ans metastases. {ECO:0000269|PubMed:11786189, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5VEI (X-ray 1.33A ) |
| DBSNP | rs725185 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:9211900}. Apical cell membrane {ECO:0000269|PubMed:18559503}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Cell projection, lamellipodium {ECO:0000269|PubMed:18559503}. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. {ECO:0000269|PubMed:18559503}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |