| Gene Information | |
|---|---|
| Gene Name | SLC4A11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 875 |
| Protein Names | Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000088836 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NBS3 |
| Gene Card | SLC4A11 |
| Uniprot ID | Q8NBS3 |
| Pfam | PF00955 |
| In ASD | no |
| Allosteric Prediction | no (-0.734059005) |
| Ortholog in Animals | Alpaca_ SLC4A11 ( ortholog_one2one ) Dog_ SLC4A11 ( ortholog_one2one ) GuineaPig_ SLC4A11 ( ortholog_one2one ) Macaque_ SLC4A11 ( ortholog_one2one ) Mouse_ Slc4a11 ( ortholog_one2one ) Pig_ SLC4A11 ( ortholog_one2one ) Rat_ Slc4a11 ( ortholog_one2one ) Rabbit_ SLC4A11 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC4A9, SLC4A3, SLC4A2, SLC4A4, SLC4A10, SLC4A5, SLC4A7, SLC4A1, SLC4A8 |
| Tissue | salivary.gland, thyroid, minor.salivary.gland |
| Tissue Specificity | Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes. {ECO:0000269|PubMed:11302728, ECO:0000269|PubMed:16767101}.; [Isoform 3]: Expressed in corneal endothelium (at protein level). {ECO:0000269|PubMed:31273259}.; [Isoform 5]: The predominant isoform in corneal endothelium (at protein level). {ECO:0000269|PubMed:31273259}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs778688114 rs200940928 rs1276051624 rs1482631297 rs34520315 rs752287261 rs141836046 rs566507872 rs759667344 rs121909395 rs762942751 rs746532062 rs1298347142 rs760889152 rs780171125 rs267607065 rs121909389 rs121909393 rs121909388 rs532728316 rs150571742 rs755379986 rs754745672 rs144734280 rs139078082 rs749826950 rs1180556979 rs267607064 rs143965185 rs267607066 rs121909387 rs757553189 rs1465111896 rs766567944 rs757244518 rs1422526172 rs144586846 rs121909394 rs34224785 rs121909396 rs121909391 rs121909392 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18024964, ECO:0000269|PubMed:25007886}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:23813972}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | HPG |
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