| Gene Information | |
|---|---|
| Gene Name | EYA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 592 |
| Protein Names | Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000104313 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99502 |
| Gene Card | EYA1 |
| Uniprot ID | Q99502 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.545295639) |
| Ortholog in Animals | Alpaca_ EYA1 ( ortholog_one2one ) Dog_ EYA1 ( ortholog_one2one ) GuineaPig_ EYA1 ( ortholog_one2one ) Macaque_ EYA1 ( ortholog_one2one ) Mouse_ Eya1 ( ortholog_one2one ) Pig_ EYA1 ( ortholog_one2one ) Rat_ Eya1 ( ortholog_one2one ) Rabbit_ EYA1 ( ortholog_one2one ) |
| Ohnologs | EYA2, EYA4, EYA3 |
| Paralogs | EYA2, EYA4, EYA3 |
| Tissue | brain, prostate |
| Tissue Specificity | In the embryo, highly expressed in kidney with lower levels in brain. Weakly expressed in lung. In the adult, highly expressed in heart and skeletal muscle. Weakly expressed in brain and liver. No expression in eye or kidney. |
| Pharmacological Animal Models | 0.039269(Chimpanzee);0.058983(Mouse);0.002101(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1445404 rs561111097 rs191838840 rs121909198 rs121909199 rs121909196 rs121909200 rs121909201 rs112340154 rs121909197 rs397517920 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12500905}. Nucleus {ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19234442}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000269|PubMed:19234442}. |
| Mouse PG classification | HPG |
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