| Gene Information | |
|---|---|
| Gene Name | LANCL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 450 |
| Protein Names | LanC-like protein 2 (Testis-specific adriamycin sensitivity protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000132434 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NS86 |
| Gene Card | LANCL2 |
| Uniprot ID | Q9NS86 |
| Pfam | PF05147 |
| In ASD | no |
| Allosteric Prediction | no (-0.999963459) |
| Ortholog in Animals | Alpaca_ LANCL2 ( ortholog_one2one ) Dog_ LANCL2 ( ortholog_one2one ) GuineaPig_ LANCL2 ( ortholog_one2one ) Macaque_ LANCL2 ( ortholog_one2one ) Mouse_ Lancl2 ( ortholog_one2one ) Pig_ LANCL2 ( ortholog_one2one ) Rat_ Lancl2 ( ortholog_one2one ) Rabbit_ LANCL2 ( ortholog_one2one ) |
| Ohnologs | LANCL1 |
| Paralogs | LANCL1, LANCL3 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain and testis. {ECO:0000269|PubMed:11762191}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6WQ1 (X-ray 2.29A ) |
| DBSNP | rs2272263 rs6961412 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12566319}. Cytoplasm {ECO:0000269|PubMed:12566319}. Cell membrane {ECO:0000269|PubMed:12566319, ECO:0000269|PubMed:16979580}. Note=Localizes to the juxta-nuclear vesicles (PubMed:16979580). Associates with the cortical actin cytoskeleton (PubMed:16979580). Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580). {ECO:0000269|PubMed:16979580}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |