| Gene Information | |
|---|---|
| Gene Name | EXT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 718 |
| Protein Names | Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2) (Putative tumor suppressor protein EXT2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000151348 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q93063 |
| Gene Card | EXT2 |
| Uniprot ID | Q93063 |
| Pfam | PF03016; PF09258 |
| In ASD | no |
| Allosteric Prediction | no (-0.624166734) |
| Ortholog in Animals | Alpaca_ EXT2 ( ortholog_one2one ) Dog_ EXT2 ( ortholog_one2one ) GuineaPig_ EXT2 ( ortholog_one2one ) Macaque_ EXT2 ( ortholog_one2one ) Mouse_ Ext2 ( ortholog_one2one ) Rat_ Ext2 ( ortholog_one2one ) Rabbit_ EXT2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EXT1, EXTL1, EXTL3, EXTL2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4755779 rs140075817 rs376292686 rs771803942 rs764379119 rs121918280 rs373582542 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:35137078}; Single-pass type II membrane protein {ECO:0000255}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus. |
| Mouse PG classification | LPG |
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