| Gene Information | |
|---|---|
| Gene Name | EXT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 746 |
| Protein Names | Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1) (Putative tumor suppressor protein EXT1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000182197 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q16394 |
| Gene Card | EXT1 |
| Uniprot ID | Q16394 |
| Pfam | PF03016; PF09258 |
| In ASD | no |
| Allosteric Prediction | no (-0.453914022) |
| Ortholog in Animals | Alpaca_ EXT1 ( ortholog_one2one ) Dog_ EXT1 ( ortholog_one2one ) GuineaPig_ EXT1 ( ortholog_one2one ) Macaque_ EXT1 ( ortholog_one2one ) Mouse_ Ext1 ( ortholog_one2one ) Pig_ EXT1 ( ortholog_one2one ) Rat_ Ext1 ( ortholog_one2one ) Rabbit_ EXT1 ( ortholog_one2one ) |
| Ohnologs | EXTL1 |
| Paralogs | EXTL1, EXT2, EXTL3, EXTL2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1554601483 rs1563659325 rs119103288 rs119103290 rs119103287 rs119103287 rs188859975 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:35137078}; Single-pass type II membrane protein {ECO:0000255}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |