| Gene Information | |
|---|---|
| Gene Name | DNPH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 174 |
| Protein Names | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) (c-Myc-responsive protein RCL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000112667 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | O43598 |
| Gene Card | DNPH1 |
| Uniprot ID | O43598 |
| Pfam | PF05014 |
| In ASD | no |
| Allosteric Prediction | no (-1.193373992) |
| Ortholog in Animals | Alpaca_ DNPH1 ( ortholog_one2one ) Dog_ DNPH1 ( ortholog_one2one ) GuineaPig_ DNPH1 ( ortholog_one2one ) Macaque_ DNPH1 ( ortholog_one2one ) Mouse_ Dnph1 ( ortholog_one2one ) Pig_ DNPH1 ( ortholog_one2one ) Rat_ Dnph1 ( ortholog_one2many ) Rabbit_ DNPH1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. {ECO:0000269|PubMed:18726892}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4P5E (X-ray 1.35A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03036, ECO:0000269|PubMed:18726892}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03036}. |
| Mouse PG classification | NA |
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