| Gene Information | |
|---|---|
| Gene Name | EXOSC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 235 |
| Protein Names | Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000077348 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NQT4 |
| Gene Card | EXOSC5 |
| Uniprot ID | Q9NQT4 |
| Pfam | PF01138; PF03725 |
| In ASD | no |
| Allosteric Prediction | no (-0.998081319) |
| Ortholog in Animals | Alpaca_ EXOSC5 ( ortholog_one2one ) Dog_ EXOSC5 ( ortholog_one2one ) GuineaPig_ EXOSC5 ( ortholog_one2one ) Macaque_ EXOSC5 ( ortholog_one2one ) Mouse_ Exosc5 ( ortholog_one2one ) Pig_ EXOSC5 ( ortholog_one2one ) Rat_ Exosc5 ( ortholog_one2one ) Rabbit_ EXOSC5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EXOSC4, EXOSC6 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.071543(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2NN6 (X-ray 3.35A ) 6D6Q (EM 3.45A ) 6D6R (EM 3.45A ) 6H25 (EM 3.80A ) |
| DBSNP | rs10853751 rs34500671 rs777418116 rs542429051 rs367988911 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}. |
| Mouse PG classification | NA |
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