| Gene Information | |
|---|---|
| Gene Name | RLF |
| Organism | Homo sapiens (Human) |
| Gene Length | 131 |
| Protein Names | Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000117000 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P51460 |
| Gene Card | INSL3 |
| Uniprot ID | P51460 |
| Pfam | PF00049 |
| In ASD | no |
| Allosteric Prediction | no (-0.94990351) |
| Ortholog in Animals | Alpaca_ RLF ( ortholog_one2one ) Dog_ RLF ( ortholog_one2one ) GuineaPig_ RLF ( ortholog_one2one ) Macaque_ RLF ( ortholog_one2one ) Mouse_ Rlf ( ortholog_one2one ) Pig_ RLF ( ortholog_one2one ) Rat_ Rlf ( ortholog_one2one ) Rabbit_ RLF ( ortholog_one2one ) |
| Ohnologs | ZNF292 |
| Paralogs | ZNF292, ZNF654 |
| Tissue | NA |
| Tissue Specificity | Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast. {ECO:0000269|PubMed:7852540}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2H8B (NMR - ) 2K6T (NMR - ) 2K6U (NMR - ) |
| DBSNP | rs186828508 rs751299877 rs6523 rs104894697 rs104894698 rs121912556 rs121912555 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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