Gene Information
Gene NameEXD2
OrganismHomo sapiens (Human)
Gene Length621
Protein NamesExonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (3'-5' exoribonuclease EXD2) (EC 3.1.13.-) (Exonuclease 3'-5' domain-like-containing protein 2)
Target NameNA
Target TypeNA
Gene Age1714 ( ENSG00000081177 )
Evolutionary StageEukaryota
AlphaFoldDBQ9NVH0
Gene CardEXD2
Uniprot IDQ9NVH0
PfamPF01612
In ASDno
Allosteric Predictionno (-1.38832442)
Ortholog in AnimalsAlpaca_ EXD2 ( ortholog_one2one )
Dog_ EXD2 ( ortholog_one2one )
GuineaPig_ EXD2 ( ortholog_one2one )
Macaque_ EXD2 ( ortholog_one2one )
Mouse_ Exd2 ( ortholog_one2one )
Pig_ EXD2 ( ortholog_one2one )
Rat_ Exd2 ( ortholog_one2one )
Rabbit_ EXD2 ( ortholog_one2one )
OhnologsNA
ParalogsEXD3
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6K17  (X-ray  1.60A  )  6K18  (X-ray  2.30A  )  6K19  (X-ray  2.20A  )  6K1A  (X-ray  2.60A  )  6K1B  (X-ray  2.60A  )  6K1C  (X-ray  2.45A  )  6K1D  (X-ray  3.00A  )  6K1E  (X-ray  2.90A  ) 
DBSNP rs35010854  rs8007859 
Subcellular location [CC]Mitochondrion outer membrane {ECO:0000269|PubMed:29599527, ECO:0000269|PubMed:31127291};
Single-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:31127291}. Mitochondrion matrix {ECO:0000269|PubMed:29335528}. Nucleus {ECO:0000269|PubMed:26807646}. Chromosome {ECO:0000269|PubMed:26807646, ECO:0000269|PubMed:31255466}. Note=Mainly localizes to the mitochondrial outer membrane (PubMed:29599527, PubMed:31127291). May translocate to the nucleus in response to DNA damage;
however mechanism that explain nuclear localization are unknown and require experimental evidences (PubMed:26807646). Recruited to replication forks following replication stress (PubMed:31255466). {ECO:0000269|PubMed:26807646, ECO:0000269|PubMed:29599527, ECO:0000269|PubMed:31127291, ECO:0000269|PubMed:31255466}.
Mouse PG classificationNA
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