| Gene Information | |
|---|---|
| Gene Name | EWSR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 441 |
| Protein Names | Protein C-ets-1 (p54) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P14921 |
| Gene Card | ETS1 |
| Uniprot ID | P14921 |
| Pfam | PF00178; PF19525; PF02198 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. {ECO:0000269|PubMed:19377509, ECO:0000269|PubMed:20378371}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1GVJ (X-ray 1.53A ) 2NNY (X-ray 2.58A ) 2STT (NMR - ) 2STW (NMR - ) 3MFK (X-ray 3.00A ) 3RI4 (X-ray 3.00A ) 3WTS (X-ray 2.35A ) 3WTT (X-ray 2.35A ) 3WTU (X-ray 2.70A ) 3WTV (X-ray 2.70A ) 3WTW (X-ray 2.90A ) 3WTX (X-ray 2.80A ) 3WTY (X-ray 2.70A ) 3WTZ (X-ray 2.61A ) 3WU0 (X-ray 2.60A ) 3WU1 (X-ray 2.40A ) 4L0Y (X-ray 2.50A ) 4L0Z (X-ray 2.70A ) 4L18 (X-ray 2.30A ) 4LG0 (X-ray 2.19A ) 5ZMC (X-ray 2.99A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:19377509}. Cytoplasm {ECO:0000269|PubMed:19377509}. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. {ECO:0000269|PubMed:19377509}. |
| Mouse PG classification | NA |
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