| Gene Information | |
|---|---|
| Gene Name | EVPL |
| Organism | Homo sapiens (Human) |
| Gene Length | 2033 |
| Protein Names | Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000167880 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q92817 |
| Gene Card | EVPL |
| Uniprot ID | Q92817 |
| Pfam | PF00681; PF17902 |
| In ASD | no |
| Allosteric Prediction | no (-0.947568802) |
| Ortholog in Animals | Alpaca_ EVPL ( ortholog_one2one ) Macaque_ EVPL ( ortholog_one2one ) Mouse_ Evpl ( ortholog_one2many ) Rat_ Evpl ( ortholog_one2many ) |
| Ohnologs | PPL |
| Paralogs | EVPLL, PPL |
| Tissue | zone.of.skin, esophagus.mucosa, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Exclusively expressed in stratified squamous epithelia. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4QMD (X-ray 1.60A ) |
| DBSNP | rs397833081 rs10445216 rs2071192 rs7342883 |
| Subcellular location [CC] | Cell junction, desmosome. Cornified envelope. Cytoplasm, cytoskeleton. Note=Colocalized with DSP at desmosomes and along intermediate filaments. |
| Mouse PG classification | NA |
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