| Gene Information | |
|---|---|
| Gene Name | ETRB |
| Organism | Homo sapiens (Human) |
| Gene Length | 442 |
| Protein Names | Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P24530 |
| Gene Card | EDNRB |
| Uniprot ID | P24530 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. {ECO:0000269|PubMed:9284755}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.350650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5GLH (X-ray 2.80A ) 5GLI (X-ray 2.50A ) 5X93 (X-ray 2.20A ) 5XPR (X-ray 3.60A ) 6IGK (X-ray 2.00A ) 6IGL (X-ray 2.70A ) 6LRY (X-ray 3.00A ) |
| DBSNP | rs12720160 rs5345 rs5346 rs1801710 rs2228271 rs5347 rs104894388 rs5350 rs104894387 rs5352 rs200363611 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:28236341}; Multi-pass membrane protein. Note=internalized after activation by endothelins. {ECO:0000269|PubMed:28236341}. |
| Mouse PG classification | NA |
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