| Gene Information | |
|---|---|
| Gene Name | CELA2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 269 |
| Protein Names | Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase-2A) |
| Target Name | chymotrypsin-like elastase family member 2a |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000142615 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08217 |
| Gene Card | CELA2A |
| Uniprot ID | P08217 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.537335887) |
| Ortholog in Animals | Alpaca_ CELA2A ( ortholog_one2one ) Mouse_ Cela2a ( ortholog_one2many ) Pig_ CELA2A ( ortholog_one2many ) Rat_ Cela2a ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CELA2B, PRTN3, ELANE, CELA1, CELA3A, CELA3B |
| Tissue | pancreas |
| Tissue Specificity | Expressed in pancreas. Not detected in keratinocytes (PubMed:10620133). Detected in exocrine secretions of the pancreas (at protein level). Also expressed in a small fraction of cells in pancreatic islets, adrenal cortex, intestinal glands and colonic lymphoid follicles (at protein level) (PubMed:31358993). Detected in plasma (PubMed:31358993). {ECO:0000269|PubMed:10620133, ECO:0000269|PubMed:31358993}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs372947070 rs558493952 rs1352544800 rs2303193 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:31358993}. |
| Mouse PG classification | NA |
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