| Gene Information |
|---|
| Gene Name | ESR1 |
|---|
| Organism | Homo sapiens (Human) |
|---|
| Gene Length | 595 |
|---|
| Protein Names | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) |
|---|
| Target Name | estrogen receptor alpha |
|---|
| Target Type | NA |
|---|
| Gene Age | 680 ( ENSG00000091831 ) |
|---|
| Evolutionary Stage | Eumetazoa |
|---|
| AlphaFoldDB | P03372 |
|---|
| Gene Card | ESR1 |
|---|
| Uniprot ID | P03372 |
|---|
| Pfam | PF12743; PF00104; PF02159; PF00105 |
|---|
| In ASD | yes |
|---|
| Allosteric Prediction | yes (1.688582333) |
|---|
| Ortholog in Animals | Alpaca_ ESR1 ( ortholog_one2one )
Dog_ ESR1 ( ortholog_one2one )
GuineaPig_ ESR1 ( ortholog_one2one )
Macaque_ ESR1 ( ortholog_one2one )
Mouse_ Esr1 ( ortholog_one2one )
Pig_ ESR1 ( ortholog_one2one )
Rat_ Esr1 ( ortholog_one2one )
Rabbit_ ESR1 ( ortholog_one2one ) |
|---|
| Ohnologs | PGR, ESRRB, ESR2, ESRRA, ESRRG |
|---|
| Paralogs | ESRRG, ESRRB, NR3C1, ESRRA, AR, ESR2, PGR, NR3C2 |
|---|
| Tissue | endometrium, oviduct, smooth.muscle, ectocervix, endocervix, uterus, vagina |
|---|
| Tissue Specificity | Widely expressed (PubMed:10970861). Not expressed in the pituitary gland (PubMed:10970861). {ECO:0000269|PubMed:10970861}.;
[Isoform 3]: Widely expressed, however not expressed in the pituitary gland. {ECO:0000269|PubMed:10970861}. |
|---|
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018634(Rabbit) |
|---|
Gene Ontology
(biological process) |
|
Gene Ontology
(cellular component) |
|
Gene Ontology
(molecular function) |
|
| PDB |
1A52
(X-ray
2.80A
)
1ERE
(X-ray
3.10A
)
1ERR
(X-ray
2.60A
)
1G50
(X-ray
2.90A
)
1GWQ
(X-ray
2.45A
)
1GWR
(X-ray
2.40A
)
1HCP
(NMR
-
)
1HCQ
(X-ray
2.40A
)
1L2I
(X-ray
1.95A
)
1PCG
(X-ray
2.70A
)
1QKT
(X-ray
2.20A
)
1QKU
(X-ray
3.20A
)
1R5K
(X-ray
2.70A
)
1SJ0
(X-ray
1.90A
)
1UOM
(X-ray
2.28A
)
1X7E
(X-ray
2.80A
)
1X7R
(X-ray
2.00A
)
1XP1
(X-ray
1.80A
)
1XP6
(X-ray
1.70A
)
1XP9
(X-ray
1.80A
)
1XPC
(X-ray
1.60A
)
1XQC
(X-ray
2.05A
)
1YIM
(X-ray
1.90A
)
1YIN
(X-ray
2.20A
)
1ZKY
(X-ray
2.25A
)
2AYR
(X-ray
1.90A
)
2B1V
(X-ray
1.80A
)
2B1Z
(X-ray
1.78A
)
2B23
(X-ray
2.10A
)
2BJ4
(X-ray
2.00A
)
2FAI
(X-ray
2.10A
)
2G44
(X-ray
2.65A
)
2G5O
(X-ray
2.30A
)
2I0J
(X-ray
2.90A
)
2IOG
(X-ray
1.60A
)
2IOK
(X-ray
2.40A
)
2JF9
(X-ray
2.10A
)
2JFA
(X-ray
2.55A
)
2LLO
(NMR
-
)
2LLQ
(NMR
-
)
2OCF
(X-ray
2.95A
)
2OUZ
(X-ray
2.00A
)
2P15
(X-ray
1.94A
)
2POG
(X-ray
1.84A
)
2Q6J
(X-ray
2.70A
)
2Q70
(X-ray
1.95A
)
2QA6
(X-ray
2.60A
)
2QA8
(X-ray
1.85A
)
2QAB
(X-ray
1.89A
)
2QE4
(X-ray
2.40A
)
2QGT
(X-ray
2.15A
)
2QGW
(X-ray
2.39A
)
2QH6
(X-ray
2.70A
)
2QR9
(X-ray
2.00A
)
2QSE
(X-ray
1.85A
)
2QXM
(X-ray
2.30A
)
2QXS
(X-ray
1.70A
)
2QZO
(X-ray
1.72A
)
2R6W
(X-ray
2.00A
)
2R6Y
(X-ray
2.00A
)
2YAT
(X-ray
2.60A
)
2YJA
(X-ray
1.82A
)
3CBM
(X-ray
1.69A
)
3CBO
(X-ray
1.65A
)
3CBP
(X-ray
1.42A
)
3DT3
(X-ray
2.40A
)
3ERD
(X-ray
2.03A
)
3ERT
(X-ray
1.90A
)
3HLV
(X-ray
3.00A
)
3HM1
(X-ray
2.33A
)
3L03
(X-ray
1.90A
)
3OS8
(X-ray
2.03A
)
3OS9
(X-ray
2.30A
)
3OSA
(X-ray
2.30A
)
3Q95
(X-ray
2.05A
)
3UU7
(X-ray
2.20A
)
3UUA
(X-ray
2.05A
)
3UUC
(X-ray
2.10A
)
3UUD
(X-ray
1.60A
)
4AA6
(X-ray
2.60A
)
4DMA
(X-ray
2.30A
)
4IU7
(X-ray
2.29A
)
4IUI
(X-ray
2.30A
)
4IV2
(X-ray
2.14A
)
4IV4
(X-ray
2.30A
)
4IVW
(X-ray
2.06A
)
4IVY
(X-ray
1.95A
)
4IW6
(X-ray
1.98A
)
4IW8
(X-ray
2.04A
)
4IWC
(X-ray
2.24A
)
4IWF
(X-ray
1.93A
)
4JC3
(X-ray
2.05A
)
4JDD
(X-ray
2.10A
)
4MG5
(X-ray
2.05A
)
4MG6
(X-ray
2.10A
)
4MG7
(X-ray
2.15A
)
4MG8
(X-ray
1.85A
)
4MG9
(X-ray
2.00A
)
4MGA
(X-ray
1.80A
)
4MGB
(X-ray
1.85A
)
4MGC
(X-ray
2.15A
)
4MGD
(X-ray
1.90A
)
4O6F
(X-ray
2.82A
)
4PP6
(X-ray
2.20A
)
4PPP
(X-ray
2.69A
)
4PPS
(X-ray
1.93A
)
4PXM
(X-ray
1.90A
)
4Q13
(X-ray
2.24A
)
4Q50
(X-ray
3.07A
)
4TUZ
(X-ray
1.90A
)
4TV1
(X-ray
1.85A
)
4XI3
(X-ray
2.49A
)
4ZN7
(X-ray
1.93A
)
4ZN9
(X-ray
2.21A
)
4ZNH
(X-ray
1.93A
)
4ZNS
(X-ray
1.86A
)
4ZNT
(X-ray
1.90A
)
4ZNU
(X-ray
2.40A
)
4ZNV
(X-ray
1.77A
)
4ZNW
(X-ray
2.31A
)
5AAU
(X-ray
1.90A
)
5AAV
(X-ray
1.95A
)
5ACC
(X-ray
1.88A
)
5AK2
(X-ray
2.19A
)
5DI7
(X-ray
2.24A
)
5DID
(X-ray
2.24A
)
5DIE
(X-ray
2.24A
)
5DIG
(X-ray
2.24A
)
5DK9
(X-ray
2.28A
)
5DKB
(X-ray
2.40A
)
5DKE
(X-ray
2.60A
)
5DKG
(X-ray
2.15A
)
5DKS
(X-ray
2.60A
)
5DL4
(X-ray
2.10A
)
5DLR
(X-ray
2.26A
)
5DMC
(X-ray
2.40A
)
5DMF
(X-ray
2.40A
)
5DP0
(X-ray
2.38A
)
5DRJ
(X-ray
2.07A
)
5DRM
(X-ray
2.24A
)
5DTV
(X-ray
2.29A
)
5DU5
(X-ray
2.19A
)
5DUE
(X-ray
2.09A
)
5DUG
(X-ray
2.25A
)
5DUH
(X-ray
2.24A
)
5DVS
(X-ray
2.28A
)
5DVV
(X-ray
2.50A
)
5DWE
(X-ray
1.92A
)
5DWG
(X-ray
2.30A
)
5DWI
(X-ray
2.43A
)
5DWJ
(X-ray
2.00A
)
5DX3
(X-ray
2.09A
)
5DXB
(X-ray
2.08A
)
5DXE
(X-ray
1.50A
)
5DXG
(X-ray
1.86A
)
5DXK
(X-ray
2.23A
)
5DXM
(X-ray
2.37A
)
5DXP
(X-ray
2.20A
)
5DXQ
(X-ray
2.40A
)
5DXR
(X-ray
2.28A
)
5DY8
(X-ray
2.03A
)
5DYB
(X-ray
2.27A
)
5DYD
(X-ray
2.48A
)
5DZ0
(X-ray
2.24A
)
5DZ1
(X-ray
2.20A
)
5DZ3
(X-ray
2.15A
)
5DZH
(X-ray
2.11A
)
5DZI
(X-ray
1.90A
)
5E0W
(X-ray
2.00A
)
5E0X
(X-ray
2.01A
)
5E14
(X-ray
2.22A
)
5E15
(X-ray
2.10A
)
5E19
(X-ray
2.24A
)
5E1C
(X-ray
1.98A
)
5EGV
(X-ray
2.86A
)
5EHJ
(X-ray
2.50A
)
5EI1
(X-ray
2.40A
)
5EIT
(X-ray
2.68A
)
5FQP
(X-ray
1.88A
)
5FQR
(X-ray
1.88A
)
5FQS
(X-ray
1.94A
)
5FQT
(X-ray
1.99A
)
5FQV
(X-ray
1.74A
)
5GS4
(X-ray
2.40A
)
5GTR
(X-ray
2.80A
)
5HYR
(X-ray
2.27A
)
5JMM
(X-ray
2.10A
)
5KCC
(X-ray
2.39A
)
5KCD
(X-ray
1.82A
)
5KCE
(X-ray
1.85A
)
5KCF
(X-ray
2.07A
)
5KCT
(X-ray
1.60A
)
5KCU
(X-ray
2.03A
)
5KCW
(X-ray
1.91A
)
5KD9
(X-ray
1.78A
)
5KR9
(X-ray
2.25A
)
5KRA
(X-ray
2.40A
)
5KRC
(X-ray
2.40A
)
5KRF
(X-ray
2.19A
)
5KRH
(X-ray
2.24A
)
5KRI
(X-ray
2.25A
)
5KRJ
(X-ray
2.70A
)
5KRK
(X-ray
2.39A
)
5KRL
(X-ray
2.40A
)
5KRM
(X-ray
2.24A
)
5KRO
(X-ray
2.10A
)
5N10
(X-ray
1.60A
)
5T0X
(NMR
-
)
5T1Z
(X-ray
2.10A
)
5T92
(X-ray
2.22A
)
5T97
(X-ray
3.00A
)
5TLD
(X-ray
2.38A
)
5TLF
(X-ray
2.20A
)
5TLG
(X-ray
2.23A
)
5TLL
(X-ray
2.42A
)
5TLM
(X-ray
2.50A
)
5TLO
(X-ray
2.28A
)
5TLP
(X-ray
2.08A
)
5TLT
(X-ray
1.90A
)
5TLU
(X-ray
2.22A
)
5TLV
(X-ray
2.32A
)
5TLX
(X-ray
2.10A
)
5TLY
(X-ray
2.14A
)
5TM1
(X-ray
2.23A
)
5TM2
(X-ray
2.60A
)
5TM3
(X-ray
2.19A
)
5TM4
(X-ray
2.25A
)
5TM5
(X-ray
2.24A
)
5TM6
(X-ray
2.54A
)
5TM7
(X-ray
2.40A
)
5TM8
(X-ray
1.99A
)
5TM9
(X-ray
2.50A
)
5TML
(X-ray
2.25A
)
5TMM
(X-ray
2.20A
)
5TMO
(X-ray
2.17A
)
5TMQ
(X-ray
2.24A
)
5TMR
(X-ray
2.30A
)
5TMS
(X-ray
2.24A
)
5TMT
(X-ray
2.05A
)
5TMU
(X-ray
2.43A
)
5TMV
(X-ray
2.38A
)
5TMW
(X-ray
2.29A
)
5TMZ
(X-ray
2.21A
)
5TN1
(X-ray
2.06A
)
5TN3
(X-ray
2.54A
)
5TN4
(X-ray
1.86A
)
5TN5
(X-ray
1.89A
)
5TN6
(X-ray
2.09A
)
5TN7
(X-ray
2.24A
)
5TN8
(X-ray
2.65A
)
5TN9
(X-ray
2.25A
)
5TNB
(X-ray
2.08A
)
5U2B
(X-ray
2.22A
)
5U2D
(X-ray
1.86A
)
5UFW
(X-ray
1.58A
)
5UFX
(X-ray
1.55A
)
5W9C
(X-ray
1.80A
)
5W9D
(X-ray
1.65A
)
5WGD
(X-ray
1.80A
)
5WGQ
(X-ray
2.30A
)
6B0F
(X-ray
2.86A
)
6C42
(X-ray
2.00A
)
6CBZ
(X-ray
1.65A
)
6CHW
(X-ray
1.89A
)
6CHZ
(X-ray
1.68A
)
6CZN
(X-ray
2.50A
)
6D0F
(X-ray
2.50A
)
6DF6
(X-ray
2.50A
)
6DFN
(X-ray
2.10A
)
6HHP
(X-ray
1.80A
)
6HKB
(X-ray
1.70A
)
6HKF
(X-ray
1.80A
)
6HMU
(X-ray
1.20A
)
6IAR
(X-ray
1.84A
)
6OWC
(X-ray
1.85A
)
6PET
(X-ray
2.20A
)
6PFM
(X-ray
2.84A
)
6PIT
(X-ray
2.25A
)
6PSJ
(X-ray
1.80A
)
6SBO
(X-ray
1.48A
)
6SQ0
(X-ray
1.77A
)
6SUO
(X-ray
1.74A
)
6TJM
(X-ray
1.85A
)
6TL3
(X-ray
2.46A
)
6V87
(X-ray
2.40A
)
6V8T
(X-ray
2.10A
)
6VGH
(X-ray
2.10A
)
6VJD
(X-ray
1.80A
)
6VPF
(X-ray
1.60A
)
6WOK
(X-ray
2.31A
)
6ZOQ
(X-ray
1.80A
)
6ZOR
(X-ray
1.97A
)
6ZOS
(X-ray
2.00A
)
7B9M
(X-ray
1.70A
)
7B9R
(X-ray
1.15A
)
7B9T
(X-ray
1.15A
)
7BA3
(X-ray
1.40A
)
7BA5
(X-ray
1.45A
)
7BA6
(X-ray
1.40A
)
7BA7
(X-ray
1.45A
)
7BA8
(X-ray
1.20A
)
7BA9
(X-ray
1.48A
)
7BAA
(X-ray
1.10A
)
7BAB
(X-ray
1.30A
)
7JHD
(X-ray
2.40A
)
7KBS
(X-ray
1.83A
)
7MSA
(X-ray
2.24A
)
7N9O
(X-ray
2.00A
)
7NDO
(X-ray
1.60A
)
7NEL
(X-ray
1.45A
)
7NFB
(X-ray
1.33A
)
7NFW
(X-ray
1.19A
)
7NIZ
(X-ray
1.48A
)
7OPW
(X-ray
1.81A
)
7OQ7
(X-ray
1.60A
)
7OQ8
(X-ray
1.43A
)
7R62
(X-ray
1.50A
)
7RKE
(X-ray
1.55A
)
7RNM
(X-ray
1.90A
)
7RRX
(X-ray
1.78A
)
7RRY
(X-ray
1.87A
)
7RRZ
(X-ray
1.83A
)
7RS0
(X-ray
1.67A
)
7RS1
(X-ray
1.59A
)
7RS2
(X-ray
1.72A
)
7RS3
(X-ray
1.84A
)
7RS4
(X-ray
1.78A
)
7RS7
(X-ray
1.58A
)
7RS8
(X-ray
1.64A
)
7RS9
(X-ray
1.70A
)
7T2X
(X-ray
2.60A
)
7TE7
(X-ray
1.85A
)
7UJ7
(X-ray
1.68A
)
7UJ8
(X-ray
2.38A
)
7UJC
(X-ray
1.78A
)
7UJF
(X-ray
1.70A
)
7UJM
(X-ray
1.80A
)
7UJO
(X-ray
1.45A
)
7UJW
(X-ray
2.60A
)
7UJY
(X-ray
1.70A
)
|
|---|
| DBSNP |
rs139960913
rs9340773
rs149308960
rs397509428
rs1131692059
|
|---|
| Subcellular location [CC] | [Isoform 1]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12682286, ECO:0000269|PubMed:20074560}. Cytoplasm {ECO:0000269|PubMed:12682286, ECO:0000269|PubMed:24498420}. Cell membrane {ECO:0000269|PubMed:12682286};
Peripheral membrane protein {ECO:0000269|PubMed:12682286};
Cytoplasmic side {ECO:0000269|PubMed:12682286}. Note=A minor fraction is associated with the inner membrane.;
[Isoform 3]: Nucleus. Cytoplasm. Cell membrane;
Peripheral membrane protein;
Cytoplasmic side. Cell membrane;
Single-pass type I membrane protein. Note=Associated with the inner membrane via palmitoylation (Probable). At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. {ECO:0000305}.;
Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated. |
|---|
| Mouse PG classification | NA |
|---|
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|---|
