| Gene Information | |
|---|---|
| Gene Name | ESX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 406 |
| Protein Names | Homeobox protein ESX1 (Extraembryonic, spermatogenesis, homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000123576 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8N693 |
| Gene Card | ESX1 |
| Uniprot ID | Q8N693 |
| Pfam | PF00046 |
| In ASD | no |
| Allosteric Prediction | no (-1.465683085) |
| Ortholog in Animals | Alpaca_ ESX1 ( ortholog_one2one ) Dog_ ESX1 ( ortholog_one2one ) Macaque_ ESX1 ( ortholog_one2one ) Mouse_ Esx1 ( ortholog_one2one ) Rat_ AABR07040695.1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PITX3, PRRX1, SHOX, SHOX2, PRRX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, DUXB, DUX4, PITX1, OTX1 |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta and testis. Expressed in testicular germ cell tumors. {ECO:0000269|PubMed:11374906, ECO:0000269|PubMed:15235584}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9697856 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15235584}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584}. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm. |
| Mouse PG classification | NA |
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