| Gene Information | |
|---|---|
| Gene Name | ERVWE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 538 |
| Protein Names | Syncytin-1 (Endogenous retrovirus group W member 1) (Env-W) (Envelope polyprotein gPr73) (Enverin) (HERV-7q Envelope protein) (HERV-W envelope protein) (HERV-W_7q21.2 provirus ancestral Env polyprotein) (Syncytin) [Cleaved into: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UQF0 |
| Gene Card | ERVW-1 |
| Uniprot ID | Q9UQF0 |
| Pfam | PF00429 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia. {ECO:0000269|PubMed:10693809, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:12970426, ECO:0000269|PubMed:15452578}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5HA6 (X-ray 2.00A ) 6RX1 (X-ray 2.10A ) |
| DBSNP | rs142852059 rs55903518 rs10266695 rs141340741 |
| Subcellular location [CC] | [Surface protein]: Cell membrane {ECO:0000305|PubMed:15827173}; Peripheral membrane protein {ECO:0000305|PubMed:15827173}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000305|PubMed:15827173}.; [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.; [Syncytin-1]: Virion {ECO:0000250}. |
| Mouse PG classification | NA |
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