Gene Information
Gene NameERVMER34-1
OrganismHomo sapiens (Human)
Gene Length563
Protein NamesEndogenous retroviral envelope protein HEMO (Endogenous retrovirus group MER34 member 1 Env polyprotein) (HERV-MER_4q12 provirus ancestral Env polyprotein) (Human endogenous MER34 (medium-reiteration-frequency-family-34) open reading frame) (Human endogenous MER34 ORF) (HEMO) [Cleaved into: Endogenous retroviral envelope protein HEMO, secreted form (Endogenous retroviral envelope protein HEMO, 48 kDa form)]
Target NameNA
Target TypeNA
Gene Age25 ( ENSG00000226887 )
Evolutionary StageMammalia
AlphaFoldDBQ9H9K5
Gene CardERVMER34-1
Uniprot IDQ9H9K5
PfamNA
In ASDno
Allosteric Predictionno (-1.56873085)
Ortholog in AnimalsAlpaca_ ERVMER34-1 ( ortholog_one2one )
Macaque_ ERVMER34-1 ( ortholog_one2one )
OhnologsNA
ParalogsERVV-1, ERVV-2, ERV3-1, ERVW-1, ERVFRD-1
Tissueplacenta
Tissue SpecificityExpressed at high level in the placenta and stem cells (at protein level) (PubMed:28739914). Also expressed in the kidney but at a lower level (PubMed:28739914). Endogenous retroviral envelope protein HEMO, secreted form: Present in the blood of pregnant women (at protein level) (PubMed:28739914). {ECO:0000269|PubMed:28739914}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC][Endogenous retroviral envelope protein HEMO]: Cell membrane {ECO:0000269|PubMed:28739914};
Single-pass type I membrane protein {ECO:0000255}. Note=This uncleaved form present at the cell surface represents the major form (PubMed:28739914). {ECO:0000269|PubMed:28739914}.;
[Endogenous retroviral envelope protein HEMO, secreted form]: Secreted {ECO:0000269|PubMed:28739914}. Note=This secreted form, which is released in the extracellular medium following cleavage, constitutes a minor form (PubMed:28739914). {ECO:0000269|PubMed:28739914}.
Mouse PG classificationNA
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