| Gene Information | |
|---|---|
| Gene Name | ERVFRD-1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 538 |
| Protein Names | Syncytin-2 (Endogenous retrovirus group FRD member 1) (Envelope polyprotein) (HERV-FRD) (HERV-FRD_6p24.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 36 ( ENSG00000244476 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P60508 |
| Gene Card | ERVFRD-1 |
| Uniprot ID | P60508 |
| Pfam | PF00429 |
| In ASD | no |
| Allosteric Prediction | no (-0.872873402) |
| Ortholog in Animals | Alpaca_ ERVFRD-1 ( ortholog_one2one ) Macaque_ ERVFRD-1 ( ortholog_one2one ) Mouse_ Synb ( ortholog_one2many ) Mouse_ Gm27179 ( ortholog_one2many ) Mouse_ Syna ( ortholog_one2many ) Rat_ Ervfrd-1 ( ortholog_one2many ) Rat_ Synb ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | ERVV-1, ERVV-2, ERV3-1, ERVMER34-1, ERVW-1 |
| Tissue | placenta |
| Tissue Specificity | Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea. {ECO:0000269|PubMed:12970426}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1Y4M (X-ray 1.60A ) 6RX3 (X-ray 2.20A ) 7OIX (EM 3.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Virion {ECO:0000305}.; [Surface protein]: Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250|UniProtKB:Q9UQF0}.; [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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