| Gene Information | |
|---|---|
| Gene Name | ERO1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 467 |
| Protein Names | ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase beta) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta) |
| Target Name | ero1-like protein beta |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000086619 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86YB8 |
| Gene Card | ERO1B |
| Uniprot ID | Q86YB8 |
| Pfam | PF04137 |
| In ASD | no |
| Allosteric Prediction | no (-0.120733686) |
| Ortholog in Animals | Alpaca_ ERO1B ( ortholog_one2one ) Dog_ ERO1B ( ortholog_one2one ) GuineaPig_ ERO1B ( ortholog_one2one ) Macaque_ ERO1B ( ortholog_one2one ) Mouse_ Ero1b ( ortholog_one2one ) Pig_ ERO1B ( ortholog_one2one ) Rat_ Ero1b ( ortholog_one2one ) Rabbit_ ERO1B ( ortholog_one2one ) |
| Ohnologs | ERO1A |
| Paralogs | ERO1A |
| Tissue | NA |
| Tissue Specificity | Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues. {ECO:0000269|PubMed:10818100, ECO:0000269|PubMed:16012172}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2477599 rs1055851 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10818100}; Peripheral membrane protein {ECO:0000269|PubMed:10818100}; Lumenal side {ECO:0000269|PubMed:10818100}. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum. |
| Mouse PG classification | NA |
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