| Gene Information | |
|---|---|
| Gene Name | ERN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 926 |
| Protein Names | Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000134398 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q76MJ5 |
| Gene Card | ERN2 |
| Uniprot ID | Q76MJ5 |
| Pfam | PF00069; PF06479 |
| In ASD | no |
| Allosteric Prediction | no (-0.39960459) |
| Ortholog in Animals | Alpaca_ ERN2 ( ortholog_one2one ) Dog_ ERN2 ( ortholog_one2one ) GuineaPig_ ERN2 ( ortholog_one2one ) Macaque_ ERN2 ( ortholog_one2one ) Mouse_ Ern2 ( ortholog_one2one ) Pig_ ERN2 ( ortholog_one2one ) Rat_ Ern2 ( ortholog_one2one ) Rabbit_ ERN2 ( ortholog_one2one ) |
| Ohnologs | ERN1 |
| Paralogs | ERN1 |
| Tissue | colon, stomach, gall.bladder, transverse.colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9932495 rs56117885 rs34683474 rs55772851 rs56191901 rs55687638 rs26764 rs56001432 rs56176960 rs56137182 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11175748}; Single-pass type I membrane protein {ECO:0000269|PubMed:11175748}. |
| Mouse PG classification | NA |
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