Gene Information
Gene NameERN1
OrganismHomo sapiens (Human)
Gene Length977
Protein NamesSerine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
Target Nameserine/threonine-protein kinase/endoribonuclease ire1
Target TypeNA
Gene Age680 ( ENSG00000178607 )
Evolutionary StageEukaryota
AlphaFoldDBO75460
Gene CardERN1
Uniprot IDO75460
PfamPF00069; PF06479
In ASDyes
Allosteric Predictionyes (0.999969133)
Ortholog in AnimalsAlpaca_ ERN1 ( ortholog_one2one )
Dog_ ERN1 ( ortholog_one2one )
GuineaPig_ ERN1 ( ortholog_one2one )
Macaque_ ERN1 ( ortholog_one2one )
Mouse_ Ern1 ( ortholog_one2one )
Pig_ ERN1 ( ortholog_one2one )
Rat_ Ern1 ( ortholog_one2one )
OhnologsERN2
ParalogsERN2
TissueNA
Tissue SpecificityUbiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269|PubMed:9637683}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2HZ6  (X-ray  3.10A  )  3P23  (X-ray  2.70A  )  4U6R  (X-ray  2.50A  )  4YZ9  (X-ray  2.46A  )  4YZC  (X-ray  2.49A  )  4YZD  (X-ray  3.10A  )  4Z7G  (X-ray  2.60A  )  4Z7H  (X-ray  2.90A  )  5HGI  (X-ray  2.58A  )  6HV0  (X-ray  2.73A  )  6HX1  (X-ray  2.14A  )  6SHC  (X-ray  3.55A  )  6URC  (X-ray  2.20A  )  6W39  (X-ray  1.74A  )  6W3A  (X-ray  2.61A  )  6W3B  (X-ray  2.57A  )  6W3C  (X-ray  2.30A  )  6W3E  (X-ray  2.74A  )  6W3K  (X-ray  2.08A  )  6XDB  (X-ray  2.45A  )  6XDD  (X-ray  2.40A  )  6XDF  (X-ray  2.54A  )  7BMK  (X-ray  1.85A  ) 
DBSNP rs1397145500  rs55869215  rs186305118  rs146710304  rs918253870  rs1279653488 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683};
Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}.
Mouse PG classificationNA
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