| Gene Information | |
|---|---|
| Gene Name | ERK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 816 |
| Protein Names | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13164 |
| Gene Card | MAPK7 |
| Uniprot ID | Q13164 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. {ECO:0000269|PubMed:7759517}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2Q8Y (X-ray 2.00A ) 4B99 (X-ray 2.80A ) 4IC7 (X-ray 2.60A ) 4IC8 (X-ray 2.80A ) 4ZSG (X-ray 1.79A ) 4ZSJ (X-ray 2.48A ) 4ZSL (X-ray 2.25A ) 5BYY (X-ray 2.79A ) 5BYZ (X-ray 1.65A ) 5O7I (X-ray 2.38A ) 6HKM (X-ray 2.47A ) 6HKN (X-ray 2.33A ) 7PUS (X-ray 2.59A ) |
| DBSNP | rs56388327 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation. |
| Mouse PG classification | NA |
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