| Gene Information | |
|---|---|
| Gene Name | ERIS |
| Organism | Homo sapiens (Human) |
| Gene Length | 379 |
| Protein Names | Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q86WV6 |
| Gene Card | STING1 |
| Uniprot ID | Q86WV6 |
| Pfam | PF15009 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages. {ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:25029335}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002528(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4EF4 (X-ray 2.15A ) 4EF5 (X-ray 2.45A ) 4EMT (X-ray 1.50A ) 4EMU (X-ray 1.90A ) 4F5D (X-ray 3.00A ) 4F5E (X-ray 2.60A ) 4F5W (X-ray 2.20A ) 4F5Y (X-ray 2.40A ) 4F9E (X-ray 2.75A ) 4F9G (X-ray 2.95A ) 4KSY (X-ray 1.88A ) 4LOH (X-ray 2.25A ) 4LOI (X-ray 1.89A ) 4QXO (X-ray 1.88A ) 4QXP (X-ray 2.51A ) 4QXQ (X-ray 2.42A ) 4QXR (X-ray 2.37A ) 5BQX (X-ray 2.00A ) 5JEJ (X-ray 2.00A ) 6CFF (X-ray 2.40A ) 6CY7 (X-ray 2.20A ) 6DNK (X-ray 1.95A ) 6DXG (X-ray 1.91A ) 6DXL (X-ray 2.45A ) 6MX0 (X-ray 1.73A ) 6MX3 (X-ray 1.36A ) 6MXE (X-ray 2.47A ) 6NT5 (EM 4.10A ) 6O8B (X-ray 3.40A ) 6O8C (X-ray 3.17A ) 6RM0 6S26 (X-ray 2.05A ) 6S27 (X-ray 2.80A ) 6S86 (X-ray 2.60A ) 6UKM (X-ray 1.74A ) 6UKU (X-ray 1.68A ) 6UKV (X-ray 1.83A ) 6UKW (X-ray 1.97A ) 6UKX (X-ray 1.93A ) 6UKY (X-ray 1.95A ) 6UKZ (X-ray 1.52A ) 6UL0 (X-ray 1.76A ) 6XF3 (X-ray 2.38A ) 6XF4 (X-ray 2.77A ) 6XNP (X-ray 1.77A ) 6Y99 (X-ray 2.98A ) 6YWA (X-ray 2.31A ) 7KVX (X-ray 2.48A ) 7KW1 (X-ray 1.80A ) |
| DBSNP | rs11554776 rs587777611 rs587777609 rs587777610 rs1131769 rs7380824 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:19285439, ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:19776740, ECO:0000269|PubMed:25254379, ECO:0000269|PubMed:29694889, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:32690950}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:32690950}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:29694889, ECO:0000269|PubMed:30842653}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:30842662, ECO:0000269|PubMed:32690950}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:32690950}. Golgi apparatus membrane {ECO:0000269|PubMed:30842653}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:30842662}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:19285439, ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:19776740}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q3TBT3}; Multi-pass membrane protein {ECO:0000255}. Note=In response to double-stranded DNA stimulation, translocates from the endoplasmic reticulum through the endoplasmic reticulum-Golgi intermediate compartment and Golgi to post-Golgi vesicles, where the kinase TBK1 is recruited (PubMed:19433799, PubMed:30842659, PubMed:30842653, PubMed:29694889). Upon cGAMP-binding, translocates to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) in a process that is dependent on COPII vesicles; STING1-containing ERGIC serves as a membrane source for LC3 lipidation, which is a key step in autophagosome biogenesis (PubMed:30842662). {ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:29694889, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:30842662, ECO:0000269|PubMed:32690950}. |
| Mouse PG classification | NA |
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