| Gene Information | |
|---|---|
| Gene Name | FLT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1338 |
| Protein Names | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) |
| Target Name | vegfr1 messenger rna |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000102755 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P17948 |
| Gene Card | FLT1 |
| Uniprot ID | P17948 |
| Pfam | PF07679; PF00047; PF07714; PF17988 |
| In ASD | no |
| Allosteric Prediction | yes (0.848112336) |
| Ortholog in Animals | Alpaca_ FLT1 ( ortholog_one2one ) Dog_ FLT1 ( ortholog_one2one ) GuineaPig_ FLT1 ( ortholog_one2one ) Macaque_ FLT1 ( ortholog_one2one ) Mouse_ Flt1 ( ortholog_one2one ) Pig_ FLT1 ( ortholog_one2one ) Rat_ Flt1 ( ortholog_one2one ) Rabbit_ FLT1 ( ortholog_one2one ) |
| Ohnologs | KDR, PDGFRA, CSF1R |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC). {ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:20512933}. |
| Pharmacological Animal Models | 0.020572(Chimpanzee);0.024788(Mouse);0.002419(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1FLT (X-ray 1.70A ) 1QSV (NMR - ) 1QSZ (NMR - ) 1QTY (X-ray 2.70A ) 1RV6 (X-ray 2.45A ) 2XAC (X-ray 2.71A ) 3HNG (X-ray 2.70A ) 4CKV (X-ray 2.06A ) 4CL7 (X-ray 2.00A ) 5ABD (X-ray 2.00A ) 5EX3 (X-ray 2.41A ) 5T89 (X-ray 4.00A ) |
| DBSNP | rs56409818 rs35073261 rs55974987 rs55687105 rs553261958 rs35549791 rs35832528 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes ubiquitination and endocytosis.; [Isoform 2]: Secreted {ECO:0000269|PubMed:8248162}.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Cytoplasm {ECO:0000305}.; [Isoform 6]: Cytoplasm {ECO:0000305}.; [Isoform 7]: Cytoplasm {ECO:0000305}. |
| Mouse PG classification | NA |
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