Gene Information

Gene Information
Gene Name	ERG1
Organism	Homo sapiens (Human)
Gene Length	1159
Protein Names	Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)
Target Name	NA
Target Type	NA
Gene Age	NA
Evolutionary Stage	NA
AlphaFoldDB	Q12809
Gene Card	KCNH2
Uniprot ID	Q12809
Pfam	PF00027; PF00520; PF13426
In ASD	yes
Allosteric Prediction	NA
Ortholog in Animals	NA
Ohnologs	NA
Paralogs	NA
Tissue	NA
Tissue Specificity	Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells. {ECO:0000269\|PubMed:18559421}.
Pharmacological Animal Models	NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit)
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1BYW (X-ray 2.60A ) 1UJL (NMR - ) 2L0W (NMR - ) 2L1M (NMR - ) 2L4R (NMR - ) 2LE7 (NMR - ) 2N7G (NMR - ) 4HP9 (X-ray 2.12A ) 4HQA (X-ray 1.96A ) 5VA1 (EM 3.70A ) 5VA2 (EM 3.80A ) 5VA3 (EM 4.00A ) 6SYG (X-ray 1.50A )
DBSNP	rs199472825 rs199473486 rs199472827 rs199472830 rs199472832 rs199472833 rs199472834 rs199473487 rs199472835 rs199472836 rs199472839 rs199473490 rs199472840 rs199473491 rs199472842 rs199472843 rs199472844 rs199472845 rs199472846 rs199472847 rs199473492 rs199472847 rs199473414 rs199473415 rs121912511 rs199473416 rs199473417 rs199473418 rs199473419 rs199473420 rs199473421 rs199473421 rs199473422 rs199473666 rs199473422 rs199472848 rs199473494 rs199472851 rs199472851 rs199472852 rs121912515 rs199472855 rs121912515 rs199472857 rs199472858 rs199472859 rs199472861 rs199473499 rs199472864 rs199472865 rs199472866 rs36210422 rs41308954 rs199472869 rs199473501 rs199472872 rs199472873 rs199472876 rs199472878 rs199472881 rs199472883 rs199472884 rs199472885 rs199473504 rs199472886 rs199472887 rs199473505 rs138776684 rs199473506 rs199472892 rs199472893 rs199473507 rs199472894 rs199472895 rs199472896 rs199472897 rs199472898 rs199472897 rs199472899 rs199472900 rs199472901 rs199473509 rs9770044 rs199472902 rs199473510 rs199472903 rs199473511 rs121912505 rs199472905 rs199472906 rs199472907 rs794728437 rs199472908 rs28928905 rs199472911 rs199472911 rs199472912 rs199472912 rs199472913 rs199472914 rs199473515 rs199472915 rs199472916 rs199473516 rs199472918 rs199472919 rs121912516 rs199472920 rs199472921 rs121912504 rs199472922 rs199472922 rs199472924 rs199473518 rs199472925 rs199472927 rs199473520 rs199472928 rs199472928 rs9333649 rs199473423 rs9333649 rs9333649 rs199473423 rs121912508 rs199473426 rs199473428 rs199473428 rs199473430 rs199473431 rs104894021 rs28928904 rs28928904 rs28928904 rs199472931 rs199472933 rs199472933 rs199472933 rs199472934 rs199472935 rs199472936 rs199472936 rs199473522 rs199472938 rs199472939 rs199472940 rs199472941 rs199472941 rs199472942 rs199472943 rs199473524 rs199472944 rs199472945 rs199472945 rs199472946 rs199472949 rs199473525 rs199472950 rs199472952 rs199472952 rs199472953 rs199473039 rs121912507 rs199472955 rs199472956 rs199472957 rs41307295 rs199472957 rs199473526 rs199472958 rs199473527 rs199472961 rs199472962 rs199472963 rs199472964 rs199472965 rs199472966 rs199472968 rs199473528 rs199472969 rs199472970 rs199473529 rs199472971 rs199472972 rs199472972 rs199472973 rs199472974 rs199472975 rs199472977 rs199472978 rs199472979 rs199472980 rs199472981 rs199472982 rs199472983 rs199472984 rs199473531 rs199473532 rs199472986 rs199473533 rs199472989 rs121912512 rs199472990 rs199472992 rs199472993 rs199472994 rs199472995 rs12720441 rs199473535 rs199472997 rs138498207 rs199472998 rs199472999 rs199472999 rs199473000 rs121912510 rs199473537 rs199473001 rs121912506 rs199473538 rs199473004 rs199473005 rs199473006 rs199473007 rs121912513 rs143512106 rs199473432 rs199473433 rs199473668 rs1805123 rs199473669 rs199473435 rs77331749 rs76420733 rs199473670 rs199473438 rs199473439 rs199473440 rs199473009 rs199473009 rs199473010 rs199473540 rs121912514 rs199473017 rs149955375 rs199473018 rs199473019 rs199473542 rs41313074 rs41307280 rs41307274 rs41307271 rs199473021 rs199473022 rs199473544 rs199473026 rs41307270 rs199473027 rs199473029 rs199473545 rs199473546 rs199473035
Subcellular location [CC]	Cell membrane {ECO:0000269\|PubMed:18559421, ECO:0000269\|PubMed:19412172, ECO:0000269\|PubMed:26363003}; Multi-pass membrane protein {ECO:0000269\|PubMed:18559421, ECO:0000269\|PubMed:19412172}.
Mouse PG classification	NA
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