| Gene Information | |
|---|---|
| Gene Name | ERCM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1186 |
| Protein Names | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (Xeroderma pigmentosum group G-complementing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P28715 |
| Gene Card | ERCC5 |
| Uniprot ID | P28715 |
| Pfam | PF00867; PF00752 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5EKF (X-ray 2.00A ) 5EKG (X-ray 2.80A ) 6TUR (X-ray 2.90A ) 6TUS (X-ray 2.50A ) 6TUW (X-ray 3.50A ) 6TUX (X-ray 3.10A ) 6VBH (X-ray 2.00A ) |
| DBSNP | rs267607281 rs121434574 rs4987063 rs4150295 rs1047769 rs4150313 rs2307491 rs4150315 rs2227869 rs4150318 rs4150319 rs1803542 rs4987168 rs121434571 rs121434575 rs121434576 rs4150342 rs267607280 rs4150387 rs9514066 rs760347832 rs587778291 rs9514067 rs17655 rs2227871 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:7651464}. Chromosome {ECO:0000269|PubMed:26833090}. Note=Colocalizes with RAD51 to nuclear foci in S phase (PubMed:26833090). Localizes to DNA double-strand breaks (DBS) during replication stress (PubMed:26833090). Colocalizes with BRCA2 to nuclear foci following DNA replication stress (PubMed:26833090). {ECO:0000269|PubMed:26833090}. |
| Mouse PG classification | NA |
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