| Gene Information | |
|---|---|
| Gene Name | ERCC8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 396 |
| Protein Names | DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000049167 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13216 |
| Gene Card | ERCC8 |
| Uniprot ID | Q13216 |
| Pfam | PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (0.275266173) |
| Ortholog in Animals | Alpaca_ ERCC8 ( ortholog_one2one ) Dog_ ERCC8 ( ortholog_one2one ) Macaque_ ERCC8 ( ortholog_one2one ) Mouse_ Ercc8 ( ortholog_one2one ) Pig_ ERCC8 ( ortholog_one2one ) Rat_ Ercc8 ( ortholog_one2one ) Rabbit_ ERCC8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GRWD1, RBBP4, GEMIN5, WDR59, WDR77, RBBP7, WDR73, PEX7, WDR24 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4A11 (X-ray 3.31A ) 6FCV (X-ray 2.92A ) 7OO3 (EM 2.80A ) 7OOB (EM 2.70A ) 7OOP (EM 2.90A ) 7OPC (EM 3.00A ) 7OPD (EM 3.00A ) |
| DBSNP | rs167037 rs281875222 rs121434325 rs281875223 rs4647105 rs281875224 rs121434326 rs281875225 rs281875221 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. Nucleus matrix {ECO:0000269|PubMed:26620705}. Note=UV-induced translocation to the nuclear matrix is dependent on ERCC6. {ECO:0000269|PubMed:26620705}. |
| Mouse PG classification | NA |
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