| Gene Information | |
|---|---|
| Gene Name | ERCC6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1493 |
| Protein Names | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000225830 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q03468 |
| Gene Card | ERCC6 |
| Uniprot ID | Q03468 |
| Pfam | PF00271; PF00176 |
| In ASD | no |
| Allosteric Prediction | yes (0.362042928) |
| Ortholog in Animals | Alpaca_ ERCC6 ( ortholog_one2one ) Dog_ ERCC6 ( ortholog_one2one ) GuineaPig_ ERCC6 ( ortholog_one2one ) Macaque_ ERCC6 ( ortholog_one2one ) Mouse_ Ercc6 ( ortholog_one2one ) Rat_ Ercc6 ( ortholog_one2one ) Rabbit_ ERCC6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SMARCA1, RAD54B, HLTF, HELLS, SHPRH, BTAF1, ZRANB3, SMARCA5, TTF2, SMARCA2, CHD9, SMARCAL1, CHD1L, CHD3, RAD54L2, SMARCAD1, CHD4, ATRX, INO80, CHD6, SRCAP, CHD1, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4CVO (X-ray 1.85A ) 7OO3 (EM 2.80A ) 7OOB (EM 2.70A ) 7OOP (EM 2.90A ) 7OPC (EM 3.00A ) 7OPD (EM 3.00A ) |
| DBSNP | rs148095899 rs2228528 rs4253046 rs4253047 rs1184760254 rs1365187961 rs202080674 rs1554788393 rs751292948 rs1026438103 rs368728467 rs2228525 rs121917905 rs4253206 rs4253208 rs2228526 rs2228527 rs34704611 rs4253211 rs2229761 rs4253219 rs34917815 rs4253227 rs4253228 rs4253229 rs2228529 rs4253230 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16128801}. |
| Mouse PG classification | NA |
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