| Gene Information | |
|---|---|
| Gene Name | ERCC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 916 |
| Protein Names | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000175595 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92889 |
| Gene Card | ERCC4 |
| Uniprot ID | Q92889 |
| Pfam | PF02732 |
| In ASD | no |
| Allosteric Prediction | yes (0.107069058) |
| Ortholog in Animals | Alpaca_ ERCC4 ( ortholog_one2one ) Dog_ ERCC4 ( ortholog_one2one ) GuineaPig_ ERCC4 ( ortholog_one2one ) Macaque_ ERCC4 ( ortholog_one2one ) Mouse_ Ercc4 ( ortholog_one2one ) Pig_ ERCC4 ( ortholog_one2one ) Rat_ Ercc4 ( ortholog_one2many ) Rabbit_ ERCC4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003276(Rat);0.062224(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Z00 (NMR - ) 2A1J (X-ray 2.70A ) 2AQ0 (NMR - ) 2KN7 (NMR - ) 2MUT (NMR - ) 6SXA (EM 3.60A ) 6SXB (EM 7.90A ) |
| DBSNP | rs34205098 rs145402255 rs121913050 rs2020961 rs764731249 rs397509402 rs397509403 rs143479220 rs1799802 rs1800067 rs912480692 rs769679311 rs1800068 rs147105770 rs2032331839 rs2020955 rs149364215 rs1800069 rs12928650 rs1451008479 rs121913049 rs4986933 rs2020957 rs1800124 rs2020956 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19596235}. Chromosome {ECO:0000269|PubMed:11790111}. Note=Localizes to sites of DNA damage. {ECO:0000269|PubMed:11790111}. |
| Mouse PG classification | NA |
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