Gene Information
Gene NameERCC3
OrganismHomo sapiens (Human)
Gene Length782
Protein NamesGeneral transcription and DNA repair factor IIH helicase subunit XPB (TFIIH subunit XPB) (EC 3.6.4.12) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000163161 )
Evolutionary StageCellular_organisms
AlphaFoldDBP19447
Gene CardERCC3
Uniprot IDP19447
PfamPF16203; PF13625; PF04851
In ASDno
Allosteric Predictionyes (0.391781326)
Ortholog in AnimalsAlpaca_ ERCC3 ( ortholog_one2one )
Dog_ ERCC3 ( ortholog_one2one )
GuineaPig_ ERCC3 ( ortholog_one2one )
Macaque_ ERCC3 ( ortholog_one2one )
Mouse_ Ercc3 ( ortholog_one2one )
Pig_ ERCC3 ( ortholog_one2one )
Rat_ Ercc3 ( ortholog_one2one )
Rabbit_ ERCC3 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.599373(Rat);0.269824(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4ERN  (X-ray  1.80A  )  5IVW  (EM  10.00A  )  5IY6  (EM  7.20A  )  5IY7  (EM  8.60A  )  5IY8  (EM  7.90A  )  5IY9  (EM  6.30A  )  5OF4  (EM  4.40A  )  6NMI  (EM  3.70A  )  6O9L  (EM  7.20A  )  6O9M  (EM  4.40A  )  6RO4  (EM  3.50A  )  7AD8  (EM  3.50A  )  7EGB  (EM  3.30A  )  7EGC  (EM  3.90A  )  7ENA  (EM  4.07A  )  7ENC  (EM  4.13A  )  7LBM  (EM  4.80A  )  7NVR  (EM  4.50A  )  7NVV  (EM  2.90A  )  7NVW  (EM  4.30A  )  7NVX  (EM  3.90A  )  7NVY  (EM  7.30A  )  7NVZ  (EM  7.20A  )  7NW0  (EM  6.60A  ) 
DBSNP rs121913045  rs1805161  rs121913046  rs1805162  rs4150521  rs4150522 
Subcellular location [CC]Nucleus.
Mouse PG classificationNA
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