| Gene Information | |
|---|---|
| Gene Name | ERCC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 760 |
| Protein Names | General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000104884 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P18074 |
| Gene Card | ERCC2 |
| Uniprot ID | P18074 |
| Pfam | PF06733; PF06777; PF13307 |
| In ASD | no |
| Allosteric Prediction | yes (0.419246638) |
| Ortholog in Animals | Alpaca_ ERCC2 ( ortholog_one2one ) Dog_ ERCC2 ( ortholog_one2one ) GuineaPig_ ERCC2 ( ortholog_one2one ) Macaque_ ERCC2 ( ortholog_one2one ) Mouse_ Ercc2 ( ortholog_one2one ) Pig_ ERCC2 ( ortholog_one2one ) Rat_ Ercc2 ( ortholog_one2one ) Rabbit_ ERCC2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DDX11, BRIP1, RTEL1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5IVW (EM 10.00A ) 5IY6 (EM 7.20A ) 5IY7 (EM 8.60A ) 5IY8 (EM 7.90A ) 5IY9 (EM 6.30A ) 5OF4 (EM 4.40A ) 6NMI (EM 3.70A ) 6O9L (EM 7.20A ) 6O9M (EM 4.40A ) 6RO4 (EM 3.50A ) 6TUN (X-ray 2.07A ) 7AD8 (EM 3.50A ) 7EGB (EM 3.30A ) 7EGC (EM 3.90A ) 7ENA (EM 4.07A ) 7ENC (EM 4.13A ) 7LBM (EM 4.80A ) 7NVR (EM 4.50A ) 7NVW (EM 4.30A ) 7NVX (EM 3.90A ) 7NVY (EM 7.30A ) 7NVZ (EM 7.20A ) 7NW0 (EM 6.60A ) |
| DBSNP | rs1360631927 rs121913020 rs1799791 rs1799792 rs1340806384 rs370454709 rs1799793 rs121913016 rs121913025 rs772572683 rs121913019 rs140522180 rs753641926 rs771824813 rs376556895 rs121913024 rs121913021 rs762141272 rs770367713 rs752510317 rs121913023 rs758439420 rs41556519 rs121913022 rs121913026 rs121913018 rs13181 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:23585563}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20797633}. |
| Mouse PG classification | NA |
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