| Gene Information | |
|---|---|
| Gene Name | ERCC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 297 |
| Protein Names | DNA excision repair protein ERCC-1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000012061 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P07992 |
| Gene Card | ERCC1 |
| Uniprot ID | P07992 |
| Pfam | PF03834 |
| In ASD | no |
| Allosteric Prediction | yes (0.101572403) |
| Ortholog in Animals | Alpaca_ ERCC1 ( ortholog_one2one ) Dog_ ERCC1 ( ortholog_one2many ) GuineaPig_ ERCC1 ( ortholog_one2one ) Macaque_ ERCC1 ( ortholog_one2one ) Mouse_ Ercc1 ( ortholog_one2one ) Pig_ ERCC1 ( ortholog_one2one ) Rat_ Ercc1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003095(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Z00 (NMR - ) 2A1I (X-ray 1.90A ) 2A1J (X-ray 2.70A ) 2JNW (NMR - ) 2JPD (NMR - ) 2MUT (NMR - ) 6SXA (EM 3.60A ) 6SXB (EM 7.90A ) |
| DBSNP | rs121913028 rs3212977 |
| Subcellular location [CC] | [Isoform 1]: Nucleus {ECO:0000269|PubMed:24036546}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:24036546}. Nucleus {ECO:0000269|PubMed:24036546}.; [Isoform 3]: Nucleus {ECO:0000269|PubMed:24036546}.; [Isoform 4]: Nucleus {ECO:0000269|PubMed:24036546}. |
| Mouse PG classification | LPG |
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