| Gene Information | |
|---|---|
| Gene Name | ERC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1116 |
| Protein Names | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000082805 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8IUD2 |
| Gene Card | ERC1 |
| Uniprot ID | Q8IUD2 |
| Pfam | PF10174; PF09457 |
| In ASD | no |
| Allosteric Prediction | no (-0.261541453) |
| Ortholog in Animals | Alpaca_ ERC1 ( ortholog_one2one ) Dog_ ERC1 ( ortholog_one2one ) GuineaPig_ ERC1 ( ortholog_one2one ) Macaque_ ERC1 ( ortholog_one2one ) Mouse_ Erc1 ( ortholog_one2one ) Pig_ ERC1 ( ortholog_one2one ) Rat_ Erc1 ( ortholog_one2one ) Rabbit_ ERC1 ( ortholog_one2one ) |
| Ohnologs | ERC2 |
| Paralogs | ERC2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested. {ECO:0000269|PubMed:12203787}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35037408 rs12319376 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27224062}. Cytoplasm {ECO:0000250|UniProtKB:Q811U3}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q811U3}. Note=Recruited on Golgi membranes by RAB6A in a GTP-dependent manner (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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