| Gene Information | |
|---|---|
| Gene Name | SLC5A7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 580 |
| Protein Names | High affinity choline transporter 1 (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7) |
| Target Name | high affinity choline transporter 1 |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000115665 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9GZV3 |
| Gene Card | SLC5A7 |
| Uniprot ID | Q9GZV3 |
| Pfam | PF00474 |
| In ASD | yes |
| Allosteric Prediction | yes (0.861341883) |
| Ortholog in Animals | Alpaca_ SLC5A7 ( ortholog_one2one ) Dog_ SLC5A7 ( ortholog_one2one ) GuineaPig_ SLC5A7 ( ortholog_one2one ) Macaque_ SLC5A7 ( ortholog_one2one ) Mouse_ Slc5a7 ( ortholog_one2one ) Pig_ SLC5A7 ( ortholog_one2one ) Rat_ Slc5a7 ( ortholog_one2one ) Rabbit_ SLC5A7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC5A11, SLC5A5, SLC5A8, SLC5A1, SLC5A6, SLC5A9, SLC5A3, SLC5A10, SLC5A4, SLC5A2, SLC5A12 |
| Tissue | pineal.gland |
| Tissue Specificity | Expressed in putamen, spinal cord and medulla. Specific for cholinergic neurons. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs886039768 rs886039765 rs1013940 rs886039766 rs1331713195 rs375397889 rs147656110 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:11027560}; Multi-pass membrane protein {ECO:0000269|PubMed:11027560}. Cell membrane {ECO:0000269|PubMed:27569547}. Synapse {ECO:0000269|PubMed:27569547}. Note=Localized at the neuromuscular junction. {ECO:0000269|PubMed:27569547}. |
| Mouse PG classification | NA |
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