Gene Information
Gene NameERBB4
OrganismHomo sapiens (Human)
Gene Length1308
Protein NamesReceptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Target Nameher4 messenger rna
Target TypeLiterature-reported target
Gene Age645 ( ENSG00000178568 )
Evolutionary StageVertebrata
AlphaFoldDBQ15303
Gene CardERBB4
Uniprot IDQ15303
PfamPF00757; PF14843; PF07714; PF01030
In ASDyes
Allosteric Predictionyes (0.999923028)
Ortholog in AnimalsAlpaca_ ERBB4 ( ortholog_one2one )
Dog_ ERBB4 ( ortholog_one2one )
GuineaPig_ ERBB4 ( ortholog_one2one )
Macaque_ ERBB4 ( ortholog_one2one )
Mouse_ Erbb4 ( ortholog_one2one )
Pig_ ERBB4 ( ortholog_one2one )
Rat_ Erbb4 ( ortholog_one2one )
Rabbit_ ERBB4 ( ortholog_one2one )
OhnologsERBB3, ERBB2, EGFR
ParalogsEPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET
TissueNA
Tissue SpecificityExpressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart. {ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2AHX  (X-ray  2.40A  )  2L2T  (NMR  -  )  2LCX  (NMR  -  )  2R4B  (X-ray  2.40A  )  3BBT  (X-ray  2.80A  )  3BBW  (X-ray  4.00A  )  3BCE  (X-ray  2.50A  )  3U2P  (X-ray  2.57A  )  3U7U  (X-ray  3.03A  )  3U9U  (X-ray  3.42A  ) 
DBSNP rs397514262  rs397514263 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263};
Single-pass type I membrane protein {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}. Note=In response to NRG1 treatment, the activated receptor is internalized.;
[ERBB4 intracellular domain]: Nucleus {ECO:0000269|PubMed:17486069}. Mitochondrion {ECO:0000269|PubMed:17486069}. Note=Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus.
Mouse PG classificationHPG
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