| Gene Information | |
|---|---|
| Gene Name | ERBB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1342 |
| Protein Names | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) |
| Target Name | erbb3 tyrosine kinase receptor |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000065361 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P21860 |
| Gene Card | ERBB3 |
| Uniprot ID | P21860 |
| Pfam | PF00757; PF14843; PF07714; PF01030 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000193015) |
| Ortholog in Animals | Alpaca_ ERBB3 ( ortholog_one2one ) Dog_ ERBB3 ( ortholog_one2one ) GuineaPig_ ERBB3 ( ortholog_one2one ) Macaque_ ERBB3 ( ortholog_one2one ) Mouse_ Erbb3 ( ortholog_one2one ) Pig_ ERBB3 ( ortholog_one2one ) Rat_ Erbb3 ( ortholog_one2one ) Rabbit_ ERBB3 ( ortholog_one2one ) |
| Ohnologs | ERBB2, EGFR, ERBB4 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Epithelial tissues and brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.207261(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1M6B (X-ray 2.60A ) 2L9U (NMR - ) 3KEX (X-ray 2.80A ) 3LMG (X-ray 2.80A ) 3P11 (X-ray 3.70A ) 4LEO (X-ray 2.64A ) 4P59 (X-ray 3.40A ) 4RIW (X-ray 3.10A ) 4RIX (X-ray 3.10A ) 4RIY (X-ray 2.98A ) 5CUS (X-ray 3.20A ) 5O4O (X-ray 3.40A ) 5O7P (X-ray 4.50A ) 6KBI (X-ray 3.00A ) 6OP9 (X-ray 2.50A ) 7BHE (X-ray 2.30A ) 7BHF (X-ray 2.00A ) 7D85 (X-ray 2.50A ) 7MN5 (EM 2.93A ) 7MN6 (EM 3.09A ) 7MN8 (EM 3.45A ) |
| DBSNP | rs34379766 rs56017157 rs1057519893 rs56107455 rs12320176 rs56387488 rs35961836 rs55787439 rs56259600 rs773123 rs2271188 rs55699040 rs55709407 rs11171743 rs755855285 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:33497358}; Single-pass type I membrane protein.; [Isoform 2]: Secreted. |
| Mouse PG classification | NA |
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