Gene Information
Gene NameERAP1
OrganismHomo sapiens (Human)
Gene Length941
Protein NamesEndoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator)
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000164307 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ9NZ08
Gene CardERAP1
Uniprot IDQ9NZ08
PfamPF11838; PF01433; PF17900
In ASDyes
Allosteric Predictionno (-0.625758666)
Ortholog in AnimalsAlpaca_ ERAP1 ( ortholog_one2one )
Dog_ ERAP1 ( ortholog_one2one )
GuineaPig_ ERAP1 ( ortholog_one2one )
Macaque_ ERAP1 ( ortholog_one2one )
Mouse_ Erap1 ( ortholog_one2one )
Pig_ ERAP1 ( ortholog_one2one )
Rat_ Erap1 ( ortholog_one2one )
Rabbit_ ERAP1 ( ortholog_one2one )
OhnologsANPEP
ParalogsRNPEPL1, NPEPPS, ENPEP, AOPEP, LTA4H, TRHDE, LNPEP, LVRN, ANPEP, RNPEP, ERAP2
TissueNA
Tissue SpecificityUbiquitous.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2YD0  (X-ray  2.70A  )  3MDJ  (X-ray  2.95A  )  3QNF  (X-ray  3.00A  )  3RJO  (X-ray  2.30A  )  5J5E  (X-ray  2.80A  )  6M8P  (X-ray  3.31A  )  6MGQ  (X-ray  2.92A  )  6Q4R  (X-ray  1.60A  )  6RQX  (X-ray  1.68A  )  6RYF  (X-ray  1.72A  )  6T6R  (X-ray  1.67A  )  7MWB  (X-ray  3.20A  )  7MWC  (X-ray  3.00A  )  7Z28  (X-ray  1.55A  ) 
DBSNP rs3734016  rs26653  rs26618  rs27895  rs2287987  rs30187  rs6863093  rs10050860  rs17482078  rs27044 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000305|PubMed:15908954};
Single-pass type II membrane protein {ECO:0000305|PubMed:15908954}.
Mouse PG classificationNA
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