| Gene Information | |
|---|---|
| Gene Name | EPT |
| Organism | Homo sapiens (Human) |
| Gene Length | 557 |
| Protein Names | Leucine-rich glioma-inactivated protein 1 (Epitempin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O95970 |
| Gene Card | LGI1 |
| Uniprot ID | O95970 |
| Pfam | PF03736; PF13855 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas. {ECO:0000269|PubMed:16518856}.; [Isoform 1]: Expressed in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices, putamen, and, particularly, in the temporal neocortex, where it is between 3 and 5 times more abundant than in the hippocampus (at protein level) (PubMed:16787412). Expression is absent in the cerebellum (PubMed:16787412). {ECO:0000269|PubMed:16787412}.; [Isoform 3]: Abundantly expressed in the occipital cortex and weakly expressed in the hippocampus (at protein level). {ECO:0000269|PubMed:16787412}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5Y2Z (X-ray 2.67A ) 5Y30 (X-ray 1.78A ) 5Y31 (X-ray 7.12A ) |
| DBSNP | rs797044996 rs797044996 rs104894166 rs119488100 rs119488099 rs104894167 rs28939075 rs28937874 rs797044999 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:16787412, ECO:0000269|PubMed:17067999, ECO:0000269|PubMed:17296837}. Synapse {ECO:0000250|UniProtKB:Q8K4Y5}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1}.; [Isoform 1]: Golgi apparatus {ECO:0000269|PubMed:17067999}. Secreted {ECO:0000269|PubMed:9879993}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1}.; [Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:17067999}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1}. |
| Mouse PG classification | NA |
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