| Gene Information | |
|---|---|
| Gene Name | EPS8L2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 715 |
| Protein Names | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000177106 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9H6S3 |
| Gene Card | EPS8L2 |
| Uniprot ID | Q9H6S3 |
| Pfam | PF08416; PF18016; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-1.172158837) |
| Ortholog in Animals | Dog_ EPS8L2 ( ortholog_one2one ) GuineaPig_ EPS8L2 ( ortholog_one2one ) Macaque_ EPS8L2 ( ortholog_one2one ) Mouse_ Eps8l2 ( ortholog_one2one ) Pig_ EPS8L2 ( ortholog_one2one ) Rat_ Eps8l2 ( ortholog_one2one ) |
| Ohnologs | EPS8L1, EPS8, EPS8L3 |
| Paralogs | EPS8L3, EPS8, EPS8L1 |
| Tissue | NA |
| Tissue Specificity | Detected in fibroblasts and placenta. {ECO:0000269|PubMed:14565974}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WWU (NMR - ) 1WXB (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14565974}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q99K30}. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells. {ECO:0000250|UniProtKB:Q99K30}. |
| Mouse PG classification | NA |
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