Gene Information
Gene NameTRPV3
OrganismHomo sapiens (Human)
Gene Length790
Protein NamesTransient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3)
Target Nametransient receptor potential cation channel subfamily v member 3
Target TypeNA
Gene Age680 ( ENSG00000167723 )
Evolutionary StageVertebrata
AlphaFoldDBQ8NET8
Gene CardTRPV3
Uniprot IDQ8NET8
PfamPF00023; PF12796; PF00520
In ASDyes
Allosteric Predictionyes (0.925290125)
Ortholog in AnimalsAlpaca_ TRPV3 ( ortholog_one2one )
Dog_ TRPV3 ( ortholog_one2one )
GuineaPig_ TRPV3 ( ortholog_one2one )
Macaque_ TRPV3 ( ortholog_one2one )
Mouse_ Trpv3 ( ortholog_one2one )
Pig_ TRPV3 ( ortholog_one2one )
Rat_ Trpv3 ( ortholog_one2one )
Rabbit_ TRPV3 ( ortholog_one2one )
OhnologsTRPV2, TRPV4, TRPV5, TRPV6
ParalogsTRPV4, TRPV2, TRPV5, TRPV6, TRPV1
Tissueskin, small.intestine
Tissue SpecificityAbundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6H9J  (X-ray  1.83A  )  6HA6  (X-ray  1.98A  )  6MHO  (EM  3.40A  )  6MHS  (EM  3.20A  )  6MHV  (EM  3.50A  )  6MHW  (EM  4.00A  )  6MHX  (EM  4.00A  )  6OT2  (EM  4.10A  )  6OT5  (EM  3.60A  )  6UW4  (EM  3.10A  )  6UW6  (EM  3.66A  )  6UW8  (EM  4.02A  )  6UW9  (EM  4.33A  )  7QQN  (X-ray  2.45A  ) 
DBSNP rs322965  rs322937  rs199473704  rs199473704  rs786205869  rs199473705  rs7212634 
Subcellular location [CC]Membrane;
Multi-pass membrane protein.
Mouse PG classificationHPG
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