| Gene Information | |
|---|---|
| Gene Name | EPS15 |
| Organism | Homo sapiens (Human) |
| Gene Length | 896 |
| Protein Names | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000085832 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P42566 |
| Gene Card | EPS15 |
| Uniprot ID | P42566 |
| Pfam | PF12763 |
| In ASD | no |
| Allosteric Prediction | yes (0.260997059) |
| Ortholog in Animals | Alpaca_ EPS15 ( ortholog_one2one ) Dog_ EPS15 ( ortholog_one2one ) GuineaPig_ EPS15 ( ortholog_one2one ) Macaque_ EPS15 ( ortholog_one2one ) Mouse_ Eps15 ( ortholog_one2one ) Pig_ EPS15 ( ortholog_one2one ) Rat_ Eps15 ( ortholog_one2one ) Rabbit_ EPS15 ( ortholog_one2one ) |
| Ohnologs | EPS15L1 |
| Paralogs | EPS15L1, REPS2, ITSN2, SRL, ITSN1, EHD2, EHD4, EHD3, REPS1, EHD1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018346(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1C07 (NMR - ) 1EH2 (NMR - ) 1F8H (NMR - ) 1FF1 (NMR - ) 2IV9 (X-ray 1.90A ) 2JXC (NMR - ) 4RH5 (X-ray 1.60A ) 4RH9 (X-ray 1.60A ) 4RHG (X-ray 1.58A ) 4S0G (X-ray 1.72A ) 5AWT (X-ray 2.70A ) 5AWU (X-ray 2.70A ) 5JP2 (X-ray 2.40A ) |
| DBSNP | rs17567 |
| Subcellular location [CC] | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. {ECO:0000269|PubMed:16159959}.; [Isoform 2]: Early endosome membrane {ECO:0000269|PubMed:18362181}; Peripheral membrane protein {ECO:0000269|PubMed:18362181}; Cytoplasmic side {ECO:0000269|PubMed:18362181}. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes. |
| Mouse PG classification | NA |
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