| Gene Information | |
|---|---|
| Gene Name | EPRS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1512 |
| Protein Names | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000136628 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P07814 |
| Gene Card | EPRS1 |
| Uniprot ID | P07814 |
| Pfam | PF00043; PF03129; PF09180; PF00749; PF03950; PF00587; PF00458 |
| In ASD | no |
| Allosteric Prediction | yes (0.668051048) |
| Ortholog in Animals | Alpaca_ EPRS1 ( ortholog_one2one ) Dog_ EPRS1 ( ortholog_one2one ) GuineaPig_ EPRS1 ( ortholog_one2one ) Macaque_ EPRS1 ( ortholog_one2one ) Mouse_ Eprs ( ortholog_one2one ) Pig_ EPRS1 ( ortholog_one2one ) Rat_ Eprs ( ortholog_one2one ) Rabbit_ EPRS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | QARS1, EARS2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.051289(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FYJ (NMR - ) 4HVC (X-ray 2.00A ) 4K86 (X-ray 2.40A ) 4K87 (X-ray 2.30A ) 4K88 (X-ray 2.62A ) 5A1N (X-ray 2.10A ) 5A34 (X-ray 2.60A ) 5A5H (X-ray 2.32A ) 5BMU (X-ray 2.60A ) 5V58 (X-ray 2.59A ) 5VAD (X-ray 2.36A ) 5Y6L (X-ray 2.90A ) 6IY6 (X-ray 3.60A ) 7BBU (X-ray 2.19A ) 7F99 (X-ray 1.98A ) 7F9C (X-ray 2.20A ) 7OSY (X-ray 2.23A ) 7OSZ (X-ray 2.46A ) 7OT0 (X-ray 2.32A ) 7OT1 (X-ray 2.71A ) 7OT2 (X-ray 2.48A ) 7OT3 (X-ray 2.53A ) |
| DBSNP | rs35999099 rs2230301 rs1063236 rs5030751 rs2230302 rs5030752 rs12144752 rs1288116010 rs1474000585 rs898824971 rs34559775 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:19289464}. Membrane {ECO:0000269|PubMed:28178239}; Peripheral membrane protein {ECO:0000305|PubMed:19289464, ECO:0000305|PubMed:28178239}. Note=Translocates from cytosol to membranes upon phosphorylation at Ser-999. {ECO:0000269|PubMed:19289464, ECO:0000269|PubMed:28178239}. |
| Mouse PG classification | NA |
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