Gene Information
Gene NameEPRS
OrganismHomo sapiens (Human)
Gene Length1512
Protein NamesBifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)]
Target Namebifunctional aminoacyl-trna synthetase
Target TypeClinical trial target
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP07814
Gene CardEPRS1
Uniprot IDP07814
PfamPF00043; PF03129; PF09180; PF00749; PF03950; PF00587; PF00458
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.051289(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1FYJ  (NMR  -  )  4HVC  (X-ray  2.00A  )  4K86  (X-ray  2.40A  )  4K87  (X-ray  2.30A  )  4K88  (X-ray  2.62A  )  5A1N  (X-ray  2.10A  )  5A34  (X-ray  2.60A  )  5A5H  (X-ray  2.32A  )  5BMU  (X-ray  2.60A  )  5V58  (X-ray  2.59A  )  5VAD  (X-ray  2.36A  )  5Y6L  (X-ray  2.90A  )  6IY6  (X-ray  3.60A  )  7BBU  (X-ray  2.19A  )  7F99  (X-ray  1.98A  )  7F9C  (X-ray  2.20A  )  7OSY  (X-ray  2.23A  )  7OSZ  (X-ray  2.46A  )  7OT0  (X-ray  2.32A  )  7OT1  (X-ray  2.71A  )  7OT2  (X-ray  2.48A  )  7OT3  (X-ray  2.53A  ) 
DBSNP rs35999099  rs2230301  rs1063236  rs5030751  rs2230302  rs5030752  rs12144752  rs1288116010  rs1474000585  rs898824971  rs34559775 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:19289464}. Membrane {ECO:0000269|PubMed:28178239};
Peripheral membrane protein {ECO:0000305|PubMed:19289464, ECO:0000305|PubMed:28178239}. Note=Translocates from cytosol to membranes upon phosphorylation at Ser-999. {ECO:0000269|PubMed:19289464, ECO:0000269|PubMed:28178239}.
Mouse PG classificationNA
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