| Gene Information | |
|---|---|
| Gene Name | EPOR |
| Organism | Homo sapiens (Human) |
| Gene Length | 508 |
| Protein Names | Erythropoietin receptor (EPO-R) |
| Target Name | erythropoietin receptor |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000187266 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P19235 |
| Gene Card | EPOR |
| Uniprot ID | P19235 |
| Pfam | PF09067; PF00041 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999648863) |
| Ortholog in Animals | Alpaca_ EPOR ( ortholog_one2one ) Dog_ EPOR ( ortholog_one2one ) GuineaPig_ EPOR ( ortholog_one2one ) Macaque_ EPOR ( ortholog_one2one ) Mouse_ Epor ( ortholog_one2one ) Pig_ EPOR ( ortholog_one2one ) Rat_ Epor ( ortholog_one2one ) Rabbit_ EPOR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MPL, IL4R, IL2RB, IL7R, IL9R, IL21R, CSF2RB |
| Tissue | NA |
| Tissue Specificity | Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002755(Rat);0.035294(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1CN4 (X-ray 2.80A ) 1EBA (X-ray 2.70A ) 1EBP (X-ray 2.80A ) 1EER (X-ray 1.90A ) 1ERN (X-ray 2.40A ) 2JIX (X-ray 3.20A ) 2MV6 (NMR - ) 4Y5V (X-ray 2.60A ) 4Y5X (X-ray 3.15A ) 4Y5Y (X-ray 2.85A ) 6E2Q (X-ray 2.65A ) 6MOE (X-ray 2.09A ) 6MOF (X-ray 2.89A ) 6MOH (X-ray 3.20A ) 6MOI (X-ray 2.06A ) 6MOJ (X-ray 2.43A ) 6MOK (X-ray 5.10A ) 6MOL (X-ray 3.16A ) |
| DBSNP | rs35423344 rs62638745 rs142094773 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]: Secreted {ECO:0000269|PubMed:11722595}. Note=Secreted and located to the cell surface. |
| Mouse PG classification | NA |
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